使用眼膏清洁眼睑治疗阻塞性睑板腺功能障碍。
Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.
作者信息
Kaido Minako, Ibrahim Osama M A, Kawashima Motoko, Ishida Reiko, Sato Enrique A, Tsubota Kazuo
机构信息
Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
Wada Eye Clinic, Chiba, Japan.
出版信息
Jpn J Ophthalmol. 2017 Jan;61(1):124-130. doi: 10.1007/s10384-016-0477-6. Epub 2016 Oct 3.
PURPOSE
To investigate the efficacy of eyelid margin cleansing with ofloxacin ophthalmic ointment in obstructive meibomian gland dysfunction (MGD) patients.
METHODS
Thirty-one eyes of 31 patients diagnosed with obstructive MGD were enrolled. All subjects were instructed to rub the eyelid edge with ofloxacin eye ointment once daily prior to bathing. Lid margin abnormalities, meibum properties, and tear stability were observed before and 3 months after ointment treatment. A questionnaire relating to the severity of MGD symptoms was administered after the treatment.
RESULTS
Vascular engorgement, meibum, dandruff-like debris, and fluorescein staining scores significantly decreased after the treatment, whereas tear break-up time significantly increased (p < 0.05). Symptoms related to MGD improved after the treatment in 86.2 % of cases.
CONCLUSIONS
Cleansing treatment ofloxacin ophthalmic ointment at the eyelid margin may be effective for patients with obstructive MGD.
目的
探讨氧氟沙星眼膏清洁睑缘对阻塞性睑板腺功能障碍（MGD）患者的疗效。
方法
纳入31例诊断为阻塞性MGD患者的31只眼。所有受试者均被指导在每日沐浴前用氧氟沙星眼膏擦拭睑缘一次。在眼膏治疗前及治疗3个月后观察睑缘异常、睑脂性质和泪膜稳定性。治疗后进行有关MGD症状严重程度的问卷调查。
结果
治疗后血管充血、睑脂、头皮屑样碎屑和荧光素染色评分显著降低，而泪膜破裂时间显著延长（p<0.05）。86.2%的病例治疗后与MGD相关的症状得到改善。
结论
氧氟沙星眼膏清洁睑缘治疗可能对阻塞性MGD患者有效。
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