Rieke Damian T, Keilholz Ulrich
Charité Comprehensive Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Recent Results Cancer Res. 2017;206:149-160. doi: 10.1007/978-3-319-43580-0_11.
Recurrent or metastatic head and neck cancer describes tumor deposits that arise locally, regionally, or at distant sites after treatment or distant metastases at the time of primary diagnosis. Prognosis for R/M squamous cell carcinomas of the head and neck (HNSCC) is poor and treatment options are limited in this situation. Human papillomavirus (HPV) is an important risk factor for HNSCC. About 40 % of all HNSCC have been attributed to HPV in Europe. HPV positivity at initial diagnosis is the single best prognostic factor for survival. However, data for the prognostic and predictive value of HPV in the R/M situation are still scarce. Due to the rising incidence of HPV-associated cancers, the number of R/M HPV+ carcinomas is also expected to rise. This chapter therefore aims to give an overview of the current knowledge concerning the role of HPV as a prognostic and predictive marker in recurrent or metastatic HNSCC.
复发性或转移性头颈癌是指在治疗后局部、区域或远处出现的肿瘤沉积物，或在初次诊断时即发生远处转移。复发性/转移性头颈部鳞状细胞癌（HNSCC）的预后较差，在这种情况下治疗选择有限。人乳头瘤病毒（HPV）是HNSCC的一个重要危险因素。在欧洲，所有HNSCC中约40%归因于HPV。初次诊断时HPV阳性是生存的单一最佳预后因素。然而，关于HPV在复发性/转移性情况下的预后和预测价值的数据仍然很少。由于HPV相关癌症的发病率不断上升，复发性/转移性HPV阳性癌的数量预计也会增加。因此，本章旨在概述目前关于HPV作为复发性或转移性HNSCC的预后和预测标志物的作用的知识。
