手术在复发性口咽癌管理中的作用
The Role of Surgery in the Management of Recurrent Oropharyngeal Cancer.
作者信息
Gross Neil D, Hanna Ehab Y
机构信息
Department Head and Neck Surgery, University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA.
出版信息
Recent Results Cancer Res. 2017;206:197-205. doi: 10.1007/978-3-319-43580-0_15.
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) continues to rise worldwide at a dramatic pace, buoyed by the predominance of human papilloma virus (HPV) driven disease (Panwar et al. 2014). While the outcomes of patients with HPV-positive OPSCC are dramatically improved compared to HPV-negative OPSCC, treatment failures do occur. The result is an inevitable rise in the incidence of recurrent OPSCC. Since the majority of incident OPSCC cases are treated with some form of radiation therapy (primary or adjuvant), surgery remains the backbone of treatment for recurrent OPSCC. This section will focus on options for surgical management of recurrent OPSCC.
在人乳头瘤病毒（HPV）驱动的疾病占主导地位的推动下，口咽鳞状细胞癌（OPSCC）的发病率在全球范围内仍在以惊人的速度持续上升（潘瓦尔等人，2014年）。虽然与HPV阴性的OPSCC相比，HPV阳性的OPSCC患者的治疗效果有了显著改善，但治疗失败的情况确实会发生。结果是复发性OPSCC的发病率不可避免地上升。由于大多数初发性OPSCC病例都接受了某种形式的放射治疗（主要或辅助），手术仍然是复发性OPSCC治疗的主要手段。本节将重点介绍复发性OPSCC的手术管理选择。
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