肌萎缩侧索硬化症中的肌间协调性：一项初步评估。
Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment.
作者信息
Issa Naoum P, Frank Samuel, Roos Raymond P, Soliven Betty, Towle Vernon L, Rezania Kourosh
机构信息
Department of Neurology, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois, 60637, USA.
出版信息
Muscle Nerve. 2017 Jun;55(6):862-868. doi: 10.1002/mus.25426. Epub 2017 Feb 3.
INTRODUCTION
Simple laboratory tests of upper motor neuron involvement in amyotrophic lateral sclerosis (ALS) are not available. Intermuscular coherence has been shown to distinguish patients with primary lateral sclerosis, a pure upper motor neuron disorder, from normal subjects, suggesting it could be useful for assessing ALS. We aimed to determine whether intermuscular coherence can distinguish ALS patients from normal subjects.
METHODS
We measured biceps brachii and brachioradialis activity using surface electromyography while subjects held the elbow at flexion and the forearm in semipronation. Intermuscular coherence was calculated at between 20 and 40 Hz in 15 ALS patients and 15 normal subjects.
RESULTS
On average, intermuscular coherence was 3.8-fold greater in normal subjects than in ALS patients (P < 0.01), and it distinguished ALS patients from normal subjects with a sensitivity of 87% and specificity of 87%.
CONCLUSION
Intermuscular coherence measurement is a rapid, painless method that may detect upper motor neuron dysfunction in ALS. Muscle Nerve 55: 862-868, 2017.
引言
目前尚无用于检测肌萎缩侧索硬化症（ALS）上运动神经元受累情况的简单实验室检查方法。已有研究表明，肌间相干性可区分原发性侧索硬化症（一种纯上运动神经元疾病）患者与正常受试者，这表明其可能有助于评估ALS。我们旨在确定肌间相干性是否能够区分ALS患者与正常受试者。
方法
在受试者保持肘部屈曲且前臂半旋前的状态下，我们使用表面肌电图测量肱二头肌和肱桡肌的活动。计算了15例ALS患者和15例正常受试者在20至40赫兹之间的肌间相干性。
结果
正常受试者的肌间相干性平均比ALS患者高3.8倍（P < 0.01），其区分ALS患者与正常受试者的灵敏度为87%，特异度为87%。
结论
肌间相干性测量是一种快速、无痛的方法，可能检测出ALS中的上运动神经元功能障碍。《肌肉与神经》55: 862 - 868, 2017年。
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