Issa Naoum P, Aydin Serdar, Goicoechea Elena Badillo, Carberry Nathan, Garret Mark A, Smith Sean, Habib Ali A, Soliven Betty, Rezania Kourosh
University of Chicago Medical Center, United States.
University of Chicago Medical Center, United States.
Clin Neurophysiol. 2025 Aug 26;179:2110986. doi: 10.1016/j.clinph.2025.2110986.
To evaluate the diagnostic potential of intermuscular coherence (IMC) measured from leg muscle pairs as an early-stage biomarker for amyotrophic lateral sclerosis (ALS).
Surface electromyography (sEMG) was recorded in neurotypical subjects and patients with early-stage ALS from muscle pairs: gastrocnemius lateralis-gastrocnemius medialis (GLGM), tibialis anterior-extensor digitorum brevis (TAED), and vastus lateralis-vastus medialis (VLVM). IMC within the 20-40 Hz range (IMCβγ) and the imaginary component of coherency in the 20-40 Hz range (ICOHβγ) were calculated. Area under the receiver operating characteristic curves (AUC) was used to assess diagnostic performance.
IMCβγ was lower in ALS patients than neurotypical subjects for all three muscle pairs (p < 0.05 in all cases). Diagnostic performance (AUC) ranged from 0.69 to 0.78 and was highest for TAED. Reducing the effect of volume conduction by using ICOHβγ tended to improve the diagnostic ability (AUC range 0.76 to 0.84).
IMCβγ from leg muscles, particularly TAED, can help differentiate early-stage ALS patients from neurotypical individuals. ICOHβγ further improves diagnostic performance by reducing volume conduction artifacts.
Leg muscle IMC measurements could aid in the early and accurate diagnosis of ALS.
评估从腿部肌肉对测量的肌间相干性（IMC）作为肌萎缩侧索硬化症（ALS）早期生物标志物的诊断潜力。
对神经正常受试者和早期ALS患者的以下肌肉对进行表面肌电图（sEMG）记录：外侧腓肠肌 - 内侧腓肠肌（GLGM）、胫骨前肌 - 趾短伸肌（TAED）以及股外侧肌 - 股内侧肌（VLVM）。计算20 - 40Hz范围内的IMC（IMCβγ）以及20 - 40Hz范围内相干性的虚部（ICOHβγ）。使用受试者工作特征曲线下面积（AUC）评估诊断性能。
对于所有三组肌肉对，ALS患者的IMCβγ均低于神经正常受试者（所有情况均为p < 0.05）。诊断性能（AUC）范围为0.69至0.78，TAED的诊断性能最高。使用ICOHβγ减少容积传导的影响倾向于提高诊断能力（AUC范围为0.76至0.84）。
来自腿部肌肉，特别是TAED的IMCβγ有助于区分早期ALS患者和神经正常个体。ICOHβγ通过减少容积传导伪影进一步提高诊断性能。
腿部肌肉IMC测量有助于ALS的早期准确诊断。
