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基于网络的应用程序“克服成瘾”以及针对问题饮酒者的线上及线下互助小组“SMART康复法”,第2部分:随机对照试验的六个月结果及参与者的定性反馈

Overcoming Addictions, a Web-Based Application, and SMART Recovery, an Online and In-Person Mutual Help Group for Problem Drinkers, Part 2: Six-Month Outcomes of a Randomized Controlled Trial and Qualitative Feedback From Participants.

作者信息

Campbell William, Hester Reid K, Lenberg Kathryn L, Delaney Harold D

机构信息

Behavior Therapy Associates, LLC, Research Division, Albuquerque, NM, United States.

出版信息

J Med Internet Res. 2016 Oct 4;18(10):e262. doi: 10.2196/jmir.5508.

DOI:10.2196/jmir.5508
PMID:27701064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5069403/
Abstract

BACKGROUND

Despite empirical evidence supporting the use of Web-based interventions for problem drinking, much remains unknown about factors that influence their effectiveness.

OBJECTIVE

We evaluated the performance of 2 resources for people who want to achieve and maintain abstinence: SMART Recovery (SR) and Overcoming Addictions (OA). OA is a Web application based on SR. We also examined participant and intervention-related factors hypothesized to impact clinical outcomes of Web-based interventions.

METHODS

We recruited 189 heavy drinkers through SR's website and in-person meetings throughout the United States. We began by randomly assigning participants to (1) SR meetings alone, (2) OA alone, and (3) OA and SR (OA+SR). Recruitment challenges compelled us to assign participants only to SR (n=86) or OA+SR (n=102). The experimental hypotheses were as follows: (1) Both groups will reduce their drinking and alcohol-related consequences at follow-up compared with their baseline levels, and (2) The OA+SR condition will reduce their drinking and alcohol or drug-related consequences more than the SR only condition. Additionally, we derived 3 groups empirically (SR, OA, and OA+SR) based on the participants' actual use of each intervention and conducted analyses by comparing them. Primary outcome measures included percent days abstinent (PDA), mean drinks per drinking day (DDD), and alcohol or drug-related consequences. Postbaseline assessments were conducted by phone at 3 and 6 months. Secondary analyses explored whether clinical issues (eg, severity of alcohol problems, level of distress, readiness to change) or intervention-related factors (eg, Internet fluency, satisfaction with site) affected outcomes.

RESULTS

Both intent-to-treat analyses and the actual-use analyses showed highly significant improvement from baseline to follow-ups for all 3 groups. Mean within-subject effect sizes were large (d>0.8) overall. There was no significant difference between groups in the amount of improvement from baseline to the average of the follow-ups. We found that participants who stopped drinking before joining the clinical trial had significantly better outcomes than participants who were still drinking when they joined the study. Neither Internet fluency nor participants' reported ease of navigating the site had an impact on outcomes.

CONCLUSIONS

These results support our first experimental hypothesis but not the second. On average, participants improved on all dependent measures. Both SR and OA helped participants recover from their problem drinking. Web-based interventions can help even those individuals with lengthy histories of heavy drinking to make clinically significant reductions in their consumption and related problems. These interventions work well for individuals in the action stage of change.

TRIAL REGISTRATION

Clinicaltrials.gov NCT01389297; https://clinicaltrials.gov/ct2/show/NCT01389297 (Archived by WebCite at http://www.webcitation.org/6kLNUNDcc).

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/36e39f452ce6/jmir_v18i10e262_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/c31943f09b6d/jmir_v18i10e262_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/501ec7f6f167/jmir_v18i10e262_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/c3fd4ff368fb/jmir_v18i10e262_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/3f770d86cddc/jmir_v18i10e262_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/32bdbeff11df/jmir_v18i10e262_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/f8a72b1ac80c/jmir_v18i10e262_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/36e39f452ce6/jmir_v18i10e262_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/c31943f09b6d/jmir_v18i10e262_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/501ec7f6f167/jmir_v18i10e262_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/c3fd4ff368fb/jmir_v18i10e262_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/3f770d86cddc/jmir_v18i10e262_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/32bdbeff11df/jmir_v18i10e262_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/f8a72b1ac80c/jmir_v18i10e262_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/5069403/36e39f452ce6/jmir_v18i10e262_fig7.jpg
摘要

背景

尽管有实证证据支持使用基于网络的干预措施来解决饮酒问题,但对于影响其有效性的因素仍有许多未知之处。

目的

我们评估了两种资源对想要实现并保持戒酒的人群的效果:SMART Recovery(SR)和克服成瘾(OA)。OA是一款基于SR的网络应用程序。我们还研究了假设会影响基于网络的干预措施临床结果的参与者和干预相关因素。

方法

我们通过SR的网站以及在美国各地的面对面会议招募了189名重度饮酒者。我们首先将参与者随机分配到(1)仅参加SR会议,(2)仅使用OA,以及(3)OA和SR(OA + SR)。招募方面的挑战迫使我们仅将参与者分配到SR组(n = 86)或OA + SR组(n = 102)。实验假设如下:(1)与基线水平相比,两组在随访时饮酒量及与酒精相关的后果都会减少,(2)OA + SR组在饮酒量及与酒精或药物相关的后果减少方面比仅使用SR组更显著。此外,我们根据参与者对每种干预措施的实际使用情况,从经验上划分出3组(SR、OA和OA + SR),并通过比较进行分析。主要结局指标包括戒酒天数百分比(PDA)、每个饮酒日的平均饮酒量(DDD)以及与酒精或药物相关的后果。在3个月和6个月时通过电话进行基线后评估。二次分析探讨了临床问题(如酒精问题的严重程度、痛苦程度、改变的意愿)或干预相关因素(如网络使用熟练度、对网站的满意度)是否会影响结局。

结果

意向性分析和实际使用分析均显示,所有3组从基线到随访都有显著改善。总体而言,平均受试者内效应量较大(d>0.8)。从基线到随访平均值的改善量在组间没有显著差异。我们发现,在加入临床试验前就已戒酒的参与者比加入研究时仍在饮酒的参与者结局显著更好。网络使用熟练度和参与者报告的网站导航易用性均未对结局产生影响。

结论

这些结果支持了我们的第一个实验假设,但不支持第二个。平均而言,参与者在所有相关指标上都有改善。SR和OA都帮助参与者从饮酒问题中恢复。基于网络的干预措施甚至可以帮助那些有长期重度饮酒史的个体在饮酒量及相关问题上实现临床上的显著减少。这些干预措施对处于改变行动阶段的个体效果良好。

试验注册

Clinicaltrials.gov NCT01389297;https://clinicaltrials.gov/ct2/show/NCT01389297(由WebCite存档于http://www.webcitation.org/6kLNUNDcc)。

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