Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR China.
Chem Rec. 2017 Mar;17(3):287-311. doi: 10.1002/tcr.201600088. Epub 2016 Oct 4.
Oxygen- and nitrogen-containing heterocyclic compounds are widely recognized as key components in many natural products and biologically relevant molecules, but often the problem comes down to methodologies in synthesizing them. Halocyclization of olefinic substrates is a promising strategy in the construction of O- and N-heterocyclic compounds, which further signifies the development of their asymmetric variants. Over the past years, our group has been devoted to this particular area of asymmetric electrophilic halocyclization with chalcogen-containing molecules as catalysts. In this account, the main focus is on the development of our novel chiral catalysts and applications derived from the reaction products.
含氧和含氮杂环化合物被广泛认为是许多天然产物和生物相关分子的关键组成部分，但通常问题在于合成它们的方法。烯烃底物的卤环化是构建 O-和 N-杂环化合物的一种很有前途的策略，进一步标志着它们的不对称变体的发展。在过去的几年里，我们小组一直致力于这一特殊领域的不对称亲电卤环化反应，使用含硫属元素的分子作为催化剂。在本报告中，主要重点是开发我们的新型手性催化剂和从反应产物中获得的应用。
