Böse Dietrich, Denmark Scott E
University of Illinois at Urbana-Champaign, Department of Chemistry, 600 S Mathews Ave., Urbana, IL 61801, USA.
Synlett. 2018 Mar;29(4):433-439. doi: 10.1055/s-0036-1590951. Epub 2017 Nov 13.
The development of catalytic, enantioselective halofunctionalizations of unactivated alkenes has made significant progress in recent years. However, the identification of generally applicable catalysts for wide range of substrates has yet to be realized. A detailed understanding of the reaction mechanism is essential to guide the formulation of a truly general catalyst. Herein, we present our investigations on the enantiodetermining step of a Lewis base catalyzed bromocycloetherification that provides important insights and design criteria.
近年来，未活化烯烃的催化对映选择性卤官能化反应取得了重大进展。然而，尚未实现针对广泛底物的通用催化剂的鉴定。对反应机理的详细理解对于指导真正通用催化剂的设计至关重要。在此，我们展示了对路易斯碱催化的溴环醚化反应对映体决定步骤的研究，该研究提供了重要的见解和设计标准。
