Weber M M, Luppa P, Engelhardt D
Medizinische Klinik II, Universität München.
Klin Wochenschr. 1989 Jul 17;67(14):707-12. doi: 10.1007/BF01721288.
The effect of ketoconazole on adrenal androgen secretion was examined in 15 patients with elevated serum androgens. In a dose of 600 mg per day orally ketoconazole inhibited the biosynthesis of all measured androgens. The mean reduction in serum levels of dehydroepiandrosterone sulfate was 32%, of dehydroepiandrosterone 54%, of androstenedione 52%, and of testosterone 43%; mean serum levels of cortisol only fell by 19%. The reduction in serum androgen levels was first significant 24 h after beginning of treatment and persisted as long as the drug was administered. We conclude that ketoconazole inhibits adrenal androgen biosynthesis more pronouncedly than cortisol biosynthesis more pronouncedly than cortisol biosynthesis. This might be of clinical benefit in the treatment of hirsutism and other states of androgen hypersecretion.
对15名血清雄激素水平升高的患者研究了酮康唑对肾上腺雄激素分泌的影响。口服剂量为每日600毫克时，酮康唑抑制了所有检测雄激素的生物合成。血清硫酸脱氢表雄酮水平平均降低32%，脱氢表雄酮降低54%，雄烯二酮降低52%，睾酮降低43%；皮质醇的平均血清水平仅下降19%。血清雄激素水平的降低在开始治疗后24小时首次显著，并在给药期间持续存在。我们得出结论，酮康唑对肾上腺雄激素生物合成的抑制作用比对皮质醇生物合成的抑制作用更显著。这可能对多毛症和其他雄激素分泌过多状态的治疗具有临床益处。
