De Pedrini P, Tommaselli A, Spanò G, Montemurro G
Istituto di I Clinica Medica Generale e Terapia Medica, Università degli studi di Roma La Sapienza, Italy.
Int J Tissue React. 1988;10(3):193-8.
Twelve women affected by functional postpuberal hirsutism were administered daily with 400 mg of ketoconazole. A significant reduction in the levels of concentration of circulating androgens (T, DEA-S, D4) was observed. A rapid clinical improvement of hirsutism and acne was noted and was even appreciable after treatment had been completed. This study is a further confirmation of the prevalent antiandrogenic action of ketoconazole, seen in its inhibiting effect on steroid synthesis in the adrenal and gonadal glands, and as such indicates that this drug is a useful alternative treatment of hirsutism in women.
12名患有青春期后功能性多毛症的女性每天服用400毫克酮康唑。观察到循环雄激素（睾酮、硫酸脱氢表雄酮、雄烯二酮）的浓度水平显著降低。多毛症和痤疮的临床症状迅速改善，且在治疗结束后仍很明显。本研究进一步证实了酮康唑普遍的抗雄激素作用，这体现在其对肾上腺和性腺类固醇合成的抑制作用上，因此表明该药物是女性多毛症的一种有效替代治疗方法。
