Hartmann Stefan, Brisam Muna, Rauthe Stephan, Driemel Oliver, Brands Roman C, Rosenwald Andreas, Kübler Alexander C, Müller-Richter Urs D A
Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, D-97070 Würzburg, Germany.
Institute of Pathology and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080 Würzburg, Germany.
Oncol Lett. 2016 Oct;12(4):2942-2947. doi: 10.3892/ol.2016.4945. Epub 2016 Aug 3.
There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (Union for International Cancer Control stage I or IV) by immunohistochemistry. MAGE-A1, -A6, -A8, -A9 and -A11 were expressed at significantly higher levels at the tumor front of stage IV specimens compared with the tumor front of stage I specimens. In stage I cancer, the tumor center and front ratio (C/F ratio) for each subgroup was >1.0. In stage IV cancer, the C/F ratio was <1.0 in 9/11 subgroups. The most significant change in the expression pattern was observed for MAGE-A11. These results indicated that there is a marked alteration and shift to the invasive front of almost all MAGE-A subgroups, but particularly MAGE-A11, during the progression of head and neck squamous cell carcinoma.
越来越多的证据表明，几个黑色素瘤相关抗原-A（MAGE-A）亚群与头颈癌的恶性程度有关。本研究通过免疫组织化学回顾性分析了38例头颈癌患者（国际癌症控制联盟I期或IV期）肿瘤前沿和中心所有已知MAGE-A亚群的表达情况。与I期标本的肿瘤前沿相比，IV期标本的肿瘤前沿中MAGE-A1、-A6、-A8、-A9和-A11的表达水平显著更高。在I期癌症中，每个亚群的肿瘤中心与前沿比值（C/F比值）>1.0。在IV期癌症中，9/11的亚群C/F比值<1.0。观察到MAGE-A11的表达模式变化最为显著。这些结果表明，在头颈部鳞状细胞癌进展过程中，几乎所有MAGE-A亚群，尤其是MAGE-A11，都有明显的改变并向浸润前沿转移。
