CRP/IL-6/IL-10单核苷酸多态性与社区获得性肺炎的易感性和严重程度相关。
CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia.
作者信息
Chou Shou-Chu, Ko How-Wen, Lin Ying-Chin
机构信息
1 Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan .
2 Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Taoyuan, Taiwan .
出版信息
Genet Test Mol Biomarkers. 2016 Dec;20(12):732-740. doi: 10.1089/gtmb.2016.0156. Epub 2016 Oct 5.
OBJECTIVE
To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP).
MATERIALS AND METHODS
Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6 -597G/A (rs1800797) and -572C/G (rs1800796), and IL-10 -592C/A (rs1800872) and -1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups.
RESULTS
The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group.
CONCLUSION
The CRP +1846C/T (rs1205), IL-6 -597G/A (rs1800797), and IL-10 -592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
目的
探讨C反应蛋白（CRP）、白细胞介素6（IL-6）和IL-10基因的单核苷酸多态性（SNP）与社区获得性肺炎（CAP）易感性及严重程度的关系。
材料与方法
选取279例CAP患者作为病例组，156例健康个体作为对照组。采用聚合酶链反应-限制性片段长度多态性方法对CRP +1059G/C（rs1800947）和+1846C/T（rs1205）、IL-6 -597G/A（rs1800797）和-572C/G（rs1800796）以及IL-10 -592C/A（rs1800872）和-1082G/A（rs1800896）进行基因分型。根据CURB-65评分，将患者分为重症社区获得性肺炎（SCAP）组和非SCAP组。
结果
病例组中CRP +1846C/T（rs1205）（CT+TT）基因型及T等位基因、IL-6 -597G/A（rs1800797）（AA+AG）基因型及A等位基因、IL-10 -592C/A（rs1800872）（CA+AA）基因型及A等位基因的频率高于对照组。此外，SCAP组中CRP +1846C/T（rs1205）（CT+TT）基因型及T等位基因、IL-6 -597G/A（rs1800797）A等位基因、IL-10 -592C/A（rs1800872）（CA+AA）基因型及A等位基因的频率高于非SCAP组。
结论
CRP +1846C/T（rs1205）、IL-6 -597G/A（rs1800797）和IL-10 -592C/A（rs1800872）可能与CAP的易感性及严重程度有关。
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