Su Guode, Ding Lili, Zhang Zhenkun
Department II of Pediatric Respiration, Xuzhou Children Hospital, Xuzhou Medical University, Xuzhou, P.R. China.
Department of Neonatology, Xuzhou Children Hospital, Xuzhou Medical University, Xuzhou, P.R. China.
Iran J Public Health. 2019 Nov;48(11):2035-2040.
To investigate the effect of interleukin-6 (IL-6) gene polymorphism on pediatric pneumonia.
Overall, 438 patients with pediatric pneumonia (Observation group) treated in Xuzhou Children Hospital, Cinna from July 2013 to July 2018 were randomly enrolled. Meanwhile, 423 healthy children (Control group) in the same time period were randomly selected. PCR was applied to amplify the IL-6-572 gene fragment. The IL-6-572 polymorphism was detected, and the impacts of gene polymorphism difference on pediatric pneumonia were observed.
There were differences in the IL-6 genotypes between the two groups (<0.05). Among the CG+GG genotypes in Observation group, G allele frequency was higher than that in control group (<0.05). The risk of pediatric pneumonia for GC genotype was 2.13 times as high as that for CC genotype, and the risk of pediatric pneumonia for GG genotype was 5.56 times as high as that for CC genotype.
IL-6 gene polymorphism might be related to the pediatric pneumonia and the population with G allele at this locus may be more prone to pediatric pneumonia.
探讨白细胞介素-6（IL-6）基因多态性对小儿肺炎的影响。
选取2013年7月至2018年7月在徐州儿童医院就诊的438例小儿肺炎患者（观察组），同时随机选取同期423例健康儿童（对照组）。采用聚合酶链反应（PCR）扩增IL-6 - 572基因片段，检测IL-6 - 572基因多态性，观察基因多态性差异对小儿肺炎的影响。
两组间IL-6基因型存在差异（<0.05）。观察组CG + GG基因型中，G等位基因频率高于对照组（<0.05）。GC基因型小儿肺炎发病风险是CC基因型的2.13倍，GG基因型小儿肺炎发病风险是CC基因型的5.56倍。
IL-6基因多态性可能与小儿肺炎有关，该位点携带G等位基因的人群可能更易患小儿肺炎。
