Galioto Rachel, Tremont Geoffrey, Blum Andrew S, LaFrance W Curt, Crook Cara L, Davis Jennifer D
From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):135-141. doi: 10.1176/appi.neuropsych.16040064. Epub 2016 Oct 6.
This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE. Depression treatment in this population could lead to improvements in cognition.
本研究通过三组人群探讨了抑郁症对颞叶癫痫（TLE）患者执行功能下降的影响：仅患有TLE的患者（TLE组；N = 29）、患有TLE且伴有抑郁症的患者（TLE + DEP组）（N = 22）以及患有抑郁症的非神经疾病参与者（DEP组；N = 31）。参与者完成了Delis-Kaplan执行功能系统测试。在许多执行功能测试中，TLE患者的表现比DEP组差。在TLE参与者中，患有抑郁症的患者表现出更差的执行功能。这些发现支持了抑郁症可能会进一步导致TLE患者执行功能困难的观点。对这一人群进行抑郁症治疗可能会改善认知功能。
