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1例在使用孟鲁司特期间出现可触及性紫癜的嗜中性皮肤病患者。

A case of neutrophilic dermatosis who develop palpable purpura during the use of montelukast.

作者信息

Çetin Gözde Yıldırım, Sayarlıoğlu Hayriye, Erhan Çiğdem, Kahraman Hasan, Cıralık Harun, Sayarlıoğlu Mehmet

机构信息

Department of Rheumatology, Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey.

Department of Nephrology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.

出版信息

Eur J Rheumatol. 2014 Dec;1(4):170-171. doi: 10.5152/eurjrheumatol.2014.140032. Epub 2014 Dec 1.

Abstract

In this case report, we present a female patient with neutrophilic dermatosis (ND) occurring as palpable purpura after using montelukast. Neutrophilic dermatoses (NDs) are characterized by skin lesions in which mature neutrophils are predominantly located in the epidermis and dermis in the absence of any infective pathology. Classification of the NDs is based upon the recognition of clinical and pathologic features, as well as the identification of associated diseases, like Sweet's syndrome, pyoderma gangrenosum, generalized pustular psoriasis, and Behçet's disease. Cutaneous findings in NDs are variable and can include vesiculopustules, plaques, nodules, or ulcerations. Drug-induced NDs are not uncommon, but ND with palpable purpura is uncommon. The current patient appeared with a rare presentation as palpable purpura without vasculitis regarding ND. It is important that this is the first case report.

摘要

在本病例报告中,我们介绍了一名女性患者,其在使用孟鲁司特后出现了作为可触及紫癜的嗜中性皮病(ND)。嗜中性皮病(NDs)的特征是皮肤病变,其中成熟嗜中性粒细胞主要位于表皮和真皮,且不存在任何感染性病理情况。NDs的分类基于对临床和病理特征的识别,以及对相关疾病的鉴定,如Sweet综合征、坏疽性脓皮病、泛发性脓疱型银屑病和白塞病。NDs的皮肤表现多样,可包括水疱脓疱、斑块、结节或溃疡。药物性NDs并不罕见,但伴有可触及紫癜的ND并不常见。该患者以罕见的表现出现,即作为可触及紫癜的ND且无血管炎。重要的是,这是首例病例报告。

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