Güneş Hakan, Kıvrak Tarık, Tatlısu Mustafa, Kaya Hakkı, Yılmaz Mehmet Birhan
Clinic of Cardiology, Sivas Numune Hospital, Sivas, Turkey.
Department of Cardiology, Cumhuriyet University Hospital, Sivas, Turkey.
Eur J Rheumatol. 2016 Jun;3(2):61-64. doi: 10.5152/eurjrheum.2016.15079. Epub 2016 Apr 5.
The aim of our study is to investigate the relationship between microalbuminuria and flow-mediated dilatation in familial Mediterranean fever (FMF) patients.
In our study, there were two groups consisting of 54 patients who were out of the attack period (43 of whom had no microalbuminuria and 11 of whom had microalbuminuria) and 40 healthy controls (M/F: 12/28).
There was no statistically difference between patient and control groups'age (25.06±8.07, 22.89±6.00 years, respectively). Flow-mediated dilatation (FMD) percentages were significantly different between the three groups (p=0.01). It was observed that there was a correlation between microalbuminuria and FMD percentage.
Endothelial dysfunction and renal damage occurred as a result of low-grade chronic inflammation. Microalbuminuria, which is the indicator of renal damage and endothelial dysfunction, and FMD show that endothelial functions can be used in the following of early detection of renal damage and endothelial functions in FMF patients.
本研究旨在探讨家族性地中海热（FMF）患者微量白蛋白尿与血流介导的血管舒张之间的关系。
在我们的研究中，有两组，一组是54例处于发作间期的患者（其中43例无微量白蛋白尿，11例有微量白蛋白尿），另一组是40名健康对照者（男/女：12/28）。
患者组和对照组的年龄无统计学差异（分别为25.06±8.07岁和22.89±6.00岁）。三组之间的血流介导的血管舒张（FMD）百分比有显著差异（p = 0.01）。观察到微量白蛋白尿与FMD百分比之间存在相关性。
低度慢性炎症导致内皮功能障碍和肾损伤。微量白蛋白尿作为肾损伤和内皮功能障碍的指标，与FMD表明内皮功能可用于FMF患者肾损伤和内皮功能早期检测的随访。
