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儿童重症心脏护理:回顾与展望

Critical cardiac care in children: looking backward and looking forward.

作者信息

Checchia Paul A

机构信息

Pediatric Cardiovascular Intensive Care, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.

出版信息

Transl Pediatr. 2016 Jul;5(3):160-164. doi: 10.21037/tp.2016.06.07.

DOI:10.21037/tp.2016.06.07
PMID:27709097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5035761/
Abstract

The growth of Pediatric Cardiovascular Intensive Care as a subspecialty has been incredible. Outcomes have improved, care delivery has matured, and research has made advances. Within this review, we take the opportunity to examine the subspecialty's past accomplishments with pride, take stock in its current state, and look forward with excitement to its future. While outcomes in general have improved dramatically, we must always be aware of the outcomes that matter to families and patients. Additionally, we must constantly ask ourselves to improve. Research into neuroprotection and individual therapeutic strategies based in genomic medicine provide the next opportunity for the subspecialty to improve.

摘要

小儿心血管重症监护作为一个亚专业的发展令人惊叹。治疗效果得到改善,护理模式逐渐成熟,研究也取得了进展。在这篇综述中,我们怀着自豪的心情回顾该亚专业过去的成就,审视其当前状况,并满怀期待地展望未来。虽然总体治疗效果有了显著改善,但我们必须始终关注对家庭和患者至关重要的治疗效果。此外,我们必须不断审视自身以求改进。基于基因组医学的神经保护和个体化治疗策略研究为该亚专业的进一步发展提供了新契机。

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New concepts in predicting, evaluating, and managing neurodevelopmental outcomes in children with congenital heart disease.预测、评估和管理先天性心脏病患儿神经发育结局的新概念。
Curr Opin Pediatr. 2013 Oct;25(5):574-84. doi: 10.1097/MOP.0b013e328365342e.
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Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children--a randomized trial.体外循环期间给予一氧化氮输送可降低儿童术后发病率——一项随机试验。
J Thorac Cardiovasc Surg. 2013 Sep;146(3):530-6. doi: 10.1016/j.jtcvs.2012.09.100. Epub 2012 Dec 8.
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Genetics and genomics in pediatric septic shock.儿科感染性休克的遗传学和基因组学。
Crit Care Med. 2012 May;40(5):1618-26. doi: 10.1097/CCM.0b013e318246b546.
4
Surgery of congenital heart disease.先天性心脏病手术
Br Med J. 1947 Sep 20;2(4524):462.
5
Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.小儿全身炎症反应综合征、脓毒症及脓毒性休克谱的基因组表达谱分析
Crit Care Med. 2009 May;37(5):1558-66. doi: 10.1097/CCM.0b013e31819fcc08.
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Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram.危重症期间对急性感染的全身炎症反应的可塑性:核糖白细胞图的发展
PLoS One. 2008 Feb 13;3(2):e1564. doi: 10.1371/journal.pone.0001564.
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Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.肽介导的Akt和细胞外调节激酶信号激活可防止淋巴细胞凋亡。
FASEB J. 2008 Feb;22(2):561-8. doi: 10.1096/fj.07-8283com. Epub 2007 Sep 13.
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The effect of surgical case volume on outcome after the Norwood procedure.诺伍德手术中手术病例数量对手术结果的影响。
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Functional genomics of critical illness and injury.
Crit Care Med. 2002 Jan;30(1 Suppl):S51-7.
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Circulation. 2001 May 15;103(19):2376-81. doi: 10.1161/01.cir.103.19.2376.