Reichardt Niels-Christian, Martín-Lomas Manuel, Penadés Soledad
CIC biomaGUNE, Glycotechnology Laboratory, Paseo Miramón 182, 20009 San Sebastian, Spain.
Chem Commun (Camb). 2016 Nov 10;52(92):13430-13439. doi: 10.1039/c6cc04445j.
In this feature article we discuss the particular relevance of glycans as components or targets of functionalized nanoparticles (NPs) for potential applications in personalized medicine but we will not enter into descriptions for their preparation. For a more general view covering the preparation and applications of glyconanomaterials the reader is referred to a number of recent reviews. The combination of glyco- and nanotechnology is already providing promising new tools for more personalized solutions to diagnostics and therapy. Current applications relevant to personalized medicine include drug targeting, localized radiation therapy, imaging of glycan expression of cancer cells, point of care diagnostics, cancer vaccines, photodynamic therapy, biosensors, and glycoproteomics.
在这篇专题文章中，我们讨论了聚糖作为功能化纳米颗粒（NPs）的组成部分或靶点在个性化医疗潜在应用中的特殊相关性，但我们不会对其制备方法进行描述。对于涵盖糖纳米材料制备和应用的更全面观点，读者可参考近期的一些综述。糖技术与纳米技术的结合已经为更个性化的诊断和治疗解决方案提供了有前景的新工具。目前与个性化医疗相关的应用包括药物靶向、局部放射治疗、癌细胞聚糖表达成像、即时诊断、癌症疫苗、光动力疗法、生物传感器和糖蛋白质组学。
