Pelevin Iu M, Zelenskaia T M
Neirofiziologiia. 1989;21(3):389-96.
Ultrastructural organization of neurosecretory cells from the hypothalamic supraoptic nuclei of aged and young rats was studied after painful stress of different duration (2 min, 20 min). Intact young rats formed the control group. An increase of the functional activity of neurosecretory cells was shown to follow the short-term stress (2 min) and a decrease of the activity--the long-term stress (20 min). The prolonged stress in young rats was comparable with ultrastructural changes in the neurosecretory cells of aged animals. The prolonged painful stress is supposed to promote the aging of the neurosecretory cells.
