Clarke A J, Stevens M T
Arch Toxicol Suppl. 1978(1):165-8. doi: 10.1007/978-3-642-66896-8_22.
The most frequent measure used to interpret drug effects on organ weights in toxicological experiments is the ratio of the organ weight to the animal's bodyweight. It is shown that in general this measure is not useful and can lead to erroneous conclusions regarding drug effects, specifically for rats. In addition a new approach to the design of organ weight experiments is considered and compared to the use of relative weights using simulated data. It is concluded that this new method may be useful in the evaluation of organ weights.
在毒理学实验中，用于解释药物对器官重量影响的最常用指标是器官重量与动物体重的比值。结果表明，一般而言，该指标并无用处，可能会导致关于药物作用的错误结论，特别是对于大鼠而言。此外，还考虑了一种器官重量实验设计的新方法，并将其与使用模拟数据的相对重量法进行比较。结论是，这种新方法可能有助于评估器官重量。
