• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相对器官重量的值。

The value of relative organ weights.

作者信息

Stevens M T

出版信息

Toxicology. 1976 Mar;5(3):311-8. doi: 10.1016/0300-483x(76)90050-0.

DOI:10.1016/0300-483x(76)90050-0
PMID:944470
Abstract

It is accepted practice in presenting organ weight data to express the results relative to the animal's body weight. The data presented suggest that in rats no benefits are obtained from this method either in reducing the variability of the data or in removing bias due to different body weights. By using simulated data it is further shown that relative weights can lead to erroneous conclusions and misinterpretation of drug effects and it is concluded that workers should present their results in absolute as opposed to relative weights.

摘要

在呈现器官重量数据时,按动物体重来表达结果是公认的做法。所呈现的数据表明,对于大鼠而言,这种方法在降低数据变异性或消除因体重不同导致的偏差方面均无益处。通过使用模拟数据进一步表明,相对重量可能会导致错误结论以及对药物效果的误解,因此得出结论:研究人员应采用绝对重量而非相对重量来呈现结果。

相似文献

1
The value of relative organ weights.相对器官重量的值。
Toxicology. 1976 Mar;5(3):311-8. doi: 10.1016/0300-483x(76)90050-0.
2
Effects of vitamin B12 on the weights of certain organs in the rat.
J Nutr. 1966 Dec;90(4):377-81. doi: 10.1093/jn/90.4.377.
3
An alternative method for the evaluation of organ weight experiments.一种评估器官重量实验的替代方法。
Toxicology. 1977 Jun;7(3):275-81. doi: 10.1016/0300-483x(77)90047-6.
4
Evaluation of organ weight differences in toxicological experiments.毒理学实验中器官重量差异的评估。
Arch Toxicol Suppl. 1978(1):165-8. doi: 10.1007/978-3-642-66896-8_22.
5
Chronic toxicity of Ponceau MX in the rat.丽春红MX对大鼠的慢性毒性
Food Cosmet Toxicol. 1966 Oct;4(5):485-92. doi: 10.1016/s0015-6264(66)80635-1.
6
Prednisolone effects upon body and organ weights, water intake, and several behaviors.泼尼松龙对体重、器官重量、饮水量及多种行为的影响。
Pharmacol Biochem Behav. 1982 Dec;17(6):1225-31. doi: 10.1016/0091-3057(82)90125-3.
7
Pituitary-related weight changes affecting the liver, uterus and adrenal glands of rats treated with hexoestrol and clomiphene in high doses.
Toxicology. 1990 Apr 17;61(2):185-94. doi: 10.1016/0300-483x(90)90019-d.
8
[Toxicity of 3',4'-dideoxykanamycin B. 2. Subacute toxicity in rats and rabbits].
Jpn J Antibiot. 1973 Jun;26(3):228-46.
9
[Toxicity of 3',4'-dideoxykanamycin B. 3. Chronic toxicity in rats and dogs].[3',4'-二脱氧卡那霉素B的毒性。3. 对大鼠和犬的慢性毒性]
Jpn J Antibiot. 1973 Jun;26(3):247-61.
10
[Josamycin propionate. 4. Toxicity].[丙酸交沙霉素。4. 毒性]
Jpn J Antibiot. 1973 Apr;26(2):136-47.

引用本文的文献

1
Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of in Rodent Studies.家蚕黄茧丝胶衍生寡肽(SDOs)在啮齿动物研究中的口服毒性和降压作用
Foods. 2024 Nov 1;13(21):3505. doi: 10.3390/foods13213505.
2
Acute and sub-chronic toxicity study of novel polyherbal formulation in non-alcoholic fatty liver using Wistar rats.新型多草药配方对Wistar大鼠非酒精性脂肪肝的急性和亚慢性毒性研究
Future Sci OA. 2024 May 20;10(1):FSO910. doi: 10.2144/fsoa-2023-0118. eCollection 2024.
3
Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights.
贝叶斯因果模型确定器官重量毒性:改进相对器官重量分析。
Sci Rep. 2020 Apr 20;10(1):6625. doi: 10.1038/s41598-020-63465-y.
4
Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats.联合服用肌醇六磷酸和肌醇补充剂可改善链脲佐菌素诱导的2型糖尿病大鼠的血清α-淀粉酶活性和血液学参数。
Adv Pharmacol Sci. 2019 Oct 15;2019:4143137. doi: 10.1155/2019/4143137. eCollection 2019.
5
The fallacy of ratio correction to address confounding factors.比值校正法应对混杂因素的谬误。
Lab Anim. 2012 Jul;46(3):245-52. doi: 10.1258/la.2012.012003.