Vecht C J, Haaxma-Reiche H, van Putten W L, de Visser M, Vries E P, Twijnstra A
Department of Neurology, Dr. Daniel den Hoed Cancer Center, Rotterdam,The Netherlands.
Neurology. 1989 Sep;39(9):1255-7. doi: 10.1212/wnl.39.9.1255.
We randomly assigned dexamethasone in an initial bolus of 10 mg IV or 100 mg IV followed by 16 mg daily orally to 37 patients with metastatic spinal cord compression. The average pain score before the start of treatment was 5.2 (SD = 2.8) and decreased significantly (p less than 0.001) to 3.8 at 3 hrs, 2.8 at 24 hrs, and 1.4 after 1 week. There were no differences between the conventional and high-dose group on pain, ambulation, or bladder function.
我们将37例转移性脊髓压迫患者随机分为两组，一组静脉注射初始剂量为10mg的地塞米松，另一组静脉注射100mg地塞米松，随后每日口服16mg。治疗开始前的平均疼痛评分为5.2（标准差=2.8），3小时时显著降至3.8（p<0.001），24小时时降至2.8，1周后降至1.4。常规剂量组和高剂量组在疼痛、行走能力或膀胱功能方面无差异。
