Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Oncology Division, Yaoundé General Hospital, Yaoundé, Cameroon.
Pan Afr Med J. 2022 Feb 23;41:163. doi: 10.11604/pamj.2022.41.163.30843. eCollection 2022.
prostate cancer represents the 3 primary neoplasia responsible for metastatic spinal cord compression (MSCC). MSCC is an extreme oncological emergency, because it involves both functional and vital prognosis. The present study aimed to establish a pattern of MSCC in prostate cancer patients in Douala and Yaoundé general hospitals (Cameroon).
this was a descriptive and retrospective study in the Radiotherapy and Medical Oncology services at both Douala and Yaoundé General Hospitals. The explored variables were general characteristics of the study population, clinical and paraclinical features, management and outcomes. Furthermore 5-year survival was analyzed by the Kaplan-Meier method. Logistic regression by determining the odd ratios and their 95% confidence was done using "Statistical Package for Social Sciences" (SPSS 23) software. The difference was considered significant at p < 0.05.
our series consisted of 151 patients out of which the mean age was 66.88 (SD: 8.71) years (95% CI: 44-88). Pain was the most common clinical symptom (53.33%; n= 80) and fracture-settlement accounted for majority (60%; n= 90.61) of the pain. Thoracic spine damage was encountered by 47.02% (n= 71). Patients received a total doses of irradiation between 20 and 30 gray (Gy). The main toxicity due to radiotherapy were asthenia (45.70%; n= 69.11). The overall survival at 5 years was 90.11%. Factors associated with fracture-settlement were smoking (aOR 10.04, 95% CI: 2.09-48.12; p = 0.004) and the localization of MSCC occurred (aOR 0.21, 95% CI: 0.05-0.77; p = 0.02).
in summary the average age for developing the condition is 66.88 years and factors associated with fracture-settlement were smoking and the localization of MSCC. Back pain was the most common clinical sign and fracture-settlement was the first type of injury on medical magnetic resonance imaging. Therefore, we recommend that emphasis should be placed on increasing awareness of the population on the importance of early diagnosis.
前列腺癌是导致转移性脊髓压迫（MSCC）的 3 种主要肿瘤之一。MSCC 是一种极端的肿瘤急症，因为它涉及功能和生存预后。本研究旨在确定杜阿拉和雅温得综合医院（喀麦隆）前列腺癌患者的 MSCC 模式。
这是一项在杜阿拉和雅温得综合医院放射治疗和肿瘤内科服务部门进行的描述性和回顾性研究。研究中探索的变量包括研究人群的一般特征、临床和辅助检查特征、治疗方法和结果。此外，还通过 Kaplan-Meier 方法分析了 5 年生存率。使用“社会科学统计软件包”（SPSS 23）软件通过确定优势比及其 95%置信区间来进行逻辑回归。差异有统计学意义（p<0.05）。
我们的研究系列包括 151 名患者，平均年龄为 66.88 岁（标准差：8.71）（95%置信区间：44-88）。疼痛是最常见的临床症状（53.33%；n=80），骨折固定占疼痛的大多数（60%；n=90.61）。胸段脊柱损伤占 47.02%（n=71）。患者接受的照射总剂量为 20 至 30 格雷（Gy）。放射治疗的主要毒性是乏力（45.70%；n=69.11）。5 年总生存率为 90.11%。与骨折固定相关的因素是吸烟（优势比 10.04，95%置信区间：2.09-48.12；p=0.004）和 MSCC 定位（优势比 0.21，95%置信区间：0.05-0.77；p=0.02）。
综上所述，发生这种情况的平均年龄为 66.88 岁，与骨折固定相关的因素是吸烟和 MSCC 的定位。背痛是最常见的临床体征，骨折固定是磁共振成像上的第一类损伤。因此，我们建议应加强对公众进行早期诊断重要性的认识。
