Griffiths L A, Hackett A M
Arch Toxicol Suppl. 1978(1):243-6. doi: 10.1007/978-3-642-66896-8_45.
Although salts of rutin on i-v admin. undergo insolubilization giving rise to concretions and suppurative inflammation in the liver this was not observed in respect of the vaso-active hydroxyethylrutosides (Pfeifer et al., 1970). I-v admin. of 3',4',7-tri0-(beta-hydroxy[14C]ethyl)-rutoside (tri-HR) and 7-mono0-(beta-hydroxy[14C]ethyl)rutoside (mono-HR) to mice showed rapid biliary excretion (approx. 71% within 24 h). Approx. 2/3 of the dose was subsequently excreted in faeces and ca. 25% in urine over 72 h. Autoradiography and scintilation counting showed short term concentration in the liver over the initial 4 h period but at 72 h less than 0.22% of tri-HR and 0.59% of mono-HR was detectable in hepatic tissue. Carcasses of mice killed at 72 h contained less than 7% of the initial dose which was mainly present in intestinal contents.
尽管芦丁盐静脉注射后会发生不溶解，导致肝脏出现结石和化脓性炎症，但血管活性羟乙基芦丁糖苷（Pfeifer等人，1970年）并未观察到这种情况。给小鼠静脉注射3',4',7-三-O-(β-羟基[14C]乙基)-芦丁糖苷（三-HR）和7-单-O-(β-羟基[14C]乙基)芦丁糖苷（单-HR）后，显示出胆汁快速排泄（24小时内约71%）。随后，约2/3的剂量在72小时内通过粪便排出，约25%通过尿液排出。放射自显影和闪烁计数显示，最初4小时内在肝脏中有短期浓度，但在72小时时，肝组织中可检测到的三-HR不到0.22%，单-HR不到0.59%。在72小时处死的小鼠尸体中，所含初始剂量不到7%，主要存在于肠道内容物中。
