Jun Myungsoo, Lee Noo Ri, Lee Won-Soo
Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
J Dermatol. 2017 Apr;44(4):386-393. doi: 10.1111/1346-8138.13613. Epub 2016 Oct 6.
Alopecia areata (AA) affects anagen hair follicles, resulting in non-scarring hair loss. Since introduced by Huang et al., superficial cryotherapy has been accepted as a considerable primary therapeutic modality for AA. The aim of this study was to objectively clarify the therapeutic efficacy and safety of superficial hypothermic cryotherapy for treatment of AA. Medical records of 353 patients from 1993 to 2014 were retrospectively analyzed. According to the response to the superficial cryotherapy, patients were categorized into four groups: "marked", "partial", "poor" and "no recovery". The marked and partial recovery groups were considered as responders. The proportions of the responders among patient subgroups which were defined by various patients, disease, and treatment factors were compared. Of the patients, 60.9% were classified as responders after 3 months of superficial hypothermic cryotherapy. The proportion of the responders were higher when the treatment interval was 2 weeks or less and in the incipient disease stage, with statistical significance. No severe side-effects other than mild pain and pruritus were reported. In conclusion, superficial cryotherapy is an effective and safe therapeutic modality for AA. Especially when the treatment interval is 2 weeks or less and in the first occurrence of the disease, the therapeutic outcome is superior.
斑秃（AA）影响生长期毛囊，导致非瘢痕性脱发。自黄等人引入以来，浅表冷冻疗法已被公认为治疗AA的一种重要的主要治疗方式。本研究的目的是客观阐明浅表低温冷冻疗法治疗AA的疗效和安全性。回顾性分析了1993年至2014年353例患者的病历。根据对浅表冷冻疗法的反应，患者被分为四组：“显著”、“部分”、“差”和“未恢复”。显著恢复组和部分恢复组被视为有反应者。比较了由各种患者、疾病和治疗因素定义的患者亚组中有反应者的比例。在接受浅表低温冷冻疗法3个月后，60.9%的患者被归类为有反应者。当治疗间隔为2周或更短且处于疾病初期时，有反应者的比例更高，具有统计学意义。除了轻微疼痛和瘙痒外，未报告严重副作用。总之，浅表冷冻疗法是治疗AA的一种有效且安全的治疗方式。特别是当治疗间隔为2周或更短且疾病首次发生时，治疗效果更佳。
