Wang Wenyan, Wang Xin, Liu Jiaqi, Gao Jidong, Wang Jie, Wang Xiang, Zhao Dongbing
Breast Surgical Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Breast Surgical Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Pathol Res Pract. 2016 Nov;212(11):1015-1020. doi: 10.1016/j.prp.2016.08.010. Epub 2016 Sep 3.
Breast cancer has aggressive clinical and pathological features in younger women and is characterized by poorer prognosis than in older women. However, data on women <25 years are limited.
The aim of the present study was to evaluate the different pathological characteristics and prognostic factors in Chinese women with breast cancer <25 years at the time of diagnosis.
This retrospective study included 94 patients (aged <25) of Chinese Han population with operable breast cancer at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences between January 1, 2000 and September 30, 2015. Univariate and multivariate Cox regression analysis were performed. The median follow-up duration was 64 months (range, 11-200 months).
The HER2-positive and triple-negative groups had a higher T (P=0.002) and N stage than the luminal A group (P=0.014). The 5-year overall survival (OS) was 90.4%, and the disease-free survival (DFS) was 74.5%. The 5-year DFS varied among the four groups were 94.1 vs. 76.9 vs. 45.5 vs. 66.7%, respectively; P=0.009. Multivariate analysis showed that only estrogen receptor (ER) status was a significant predictor of OS and DFS [Hazard ratio (HR)=5.3, 95% confidence interval (CI)=1.11-25.27, P=0.036; HR=2.712, 95%CI=1.27-5.80, P=0.01).
HER2-positive and triple-negative breast cancer are more likely to have poor prognosis in patients<25years. Hence, ER status may be identified as an independent prognostic factor for predicting young women with breast cancer.
年轻女性乳腺癌具有侵袭性的临床和病理特征，其预后较老年女性更差。然而，关于25岁以下女性的数据有限。
本研究旨在评估中国诊断时年龄小于25岁的乳腺癌女性的不同病理特征和预后因素。
这项回顾性研究纳入了2000年1月1日至2015年9月30日期间在中国医学科学院肿瘤医院/国家癌症中心就诊的94例年龄小于25岁的中国汉族可手术乳腺癌患者。进行单因素和多因素Cox回归分析。中位随访时间为64个月（范围11 - 200个月）。
HER2阳性和三阴性组的T分期（P = 0.002）和N分期高于腔面A型组（P = 0.014）。5年总生存率（OS）为90.4%，无病生存率（DFS）为74.5%。四组的5年DFS分别为94.1%、76.9%、45.5%和66.7%；P = 0.009。多因素分析显示，只有雌激素受体（ER）状态是OS和DFS的显著预测因素[风险比（HR）= 5.3，95%置信区间（CI）= 1.11 - 25.27，P = 0.036；HR = 2.712, 95%CI = 1.27 - 5.80, P = 0.01]。
HER2阳性和三阴性乳腺癌在25岁以下患者中预后更差。因此，ER状态可被确定为预测年轻乳腺癌女性的独立预后因素。
