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肥胖症药物的获批用途和未获批准的使用情况,以及潜在的新药物治疗选择。

Approved and Off-Label Uses of Obesity Medications, and Potential New Pharmacologic Treatment Options.

作者信息

Isidro Mª Luisa, Cordido Fernando

机构信息

Endocrine Department, Complejo Hospitalario Universitario A Coruña As Xubias 84, 15006 A Coruña, Spain.

出版信息

Pharmaceuticals (Basel). 2010 Jan 12;3(1):125-145. doi: 10.3390/ph3010125.

DOI:10.3390/ph3010125
PMID:27713245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3991023/
Abstract

Available anti-obesity pharmacotherapy options remain very limited and development of more effective drugs has become a priority. The potential strategies to achieve weight loss are to reduce energy intake by stimulating anorexigenic signals or by blocking orexigenic signals, and to increase energy expenditure. This review will focus on approved obesity medications, as well as potential new pharmacologic treatment options.

摘要

现有的抗肥胖药物治疗选择仍然非常有限,开发更有效的药物已成为当务之急。实现体重减轻的潜在策略是通过刺激厌食信号或阻断食欲信号来减少能量摄入,以及增加能量消耗。本综述将重点关注已获批的肥胖症药物以及潜在的新药物治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/1a99e8051bf7/pharmaceuticals-03-00125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/8af63fa93638/pharmaceuticals-03-00125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/a47091a4debb/pharmaceuticals-03-00125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/b61d991b562c/pharmaceuticals-03-00125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/42dfc34ab5b0/pharmaceuticals-03-00125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/1a99e8051bf7/pharmaceuticals-03-00125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/8af63fa93638/pharmaceuticals-03-00125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/a47091a4debb/pharmaceuticals-03-00125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/b61d991b562c/pharmaceuticals-03-00125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/42dfc34ab5b0/pharmaceuticals-03-00125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d5/3991023/1a99e8051bf7/pharmaceuticals-03-00125-g005.jpg

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本文引用的文献

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Anti-obesity agents: a focused review on the structural classification of therapeutic entities.抗肥胖药物:治疗实体结构分类的重点综述。
Curr Top Med Chem. 2009;9(6):466-81. doi: 10.2174/156802609788897862.
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Synthesis and structure-activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands.新型二芳基吡唑酰亚胺类似物作为CB1大麻素受体配体的合成及构效关系
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Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects.奥利司他可加速健康受试者的胃排空并减弱其胃肠抑胃肽的释放。
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A critical review of the cannabinoid receptor as a drug target for obesity management.对大麻素受体作为肥胖管理药物靶点的批判性综述。
Obes Rev. 2009 Jan;10(1):58-67. doi: 10.1111/j.1467-789X.2008.00520.x. Epub 2008 Aug 20.
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The endocannabinoid system and energy metabolism.内源性大麻素系统与能量代谢。
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Curr Opin Drug Discov Devel. 2008 Jul;11(4):438-45.
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