Vassilakopoulos Theodoros, Toumpanakis Dimitrios
Pulmonary and Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Int J Chron Obstruct Pulmon Dis. 2016 Sep 26;11:2377-2384. doi: 10.2147/COPD.S113877. eCollection 2016.
In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence.
在阻塞性肺疾病中，气道炎症会导致支气管痉挛，进而引起呼吸阻力增加，尤其是在病情加重期间。本评论讨论了实验证据，即在没有潜在气道炎症的情况下，呼吸阻力本身（机械刺激）会导致肺损伤和炎症（机械转导）。文中还介绍了呼吸阻力诱导的机械转导在慢性阻塞性肺疾病加重期的潜在影响以及现有的临床证据。
