Camacho-Muñoz Dolores, Petrie Bruce, Castrignanò Erika, Kasprzyk-Hordern Barbara
Department of Chemistry, University of Bath, Bath, United Kingdom.
Curr Anal Chem. 2016 Aug;12(4):303-314. doi: 10.2174/1573411012666151009195039.
The issue of drug chirality is attracting increasing attention among the scientific community. The phenomenon of chirality has been overlooked in environmental research (environmental occurrence, fate and toxicity) despite the great impact that chiral pharmacologically active compounds (cPACs) can provoke on ecosystems. The aim of this paper is to introduce the topic of chirality and its implications in environmental contamination. Special attention has been paid to the most recent advances in chiral analysis based on liquid chromatography coupled with mass spectrometry and the most popular protein based chiral stationary phases. Several groups of cPACs of environmental relevance, such as illicit drugs, human and veterinary medicines were discussed. The increase in the number of papers published in the area of chiral environmental analysis indicates that researchers are actively pursuing new opportunities to provide better understanding of environmental impacts resulting from the enantiomerism of cPACs.
药物手性问题在科学界正受到越来越多的关注。尽管手性药理活性化合物（cPACs）会对生态系统产生重大影响，但手性现象在环境研究（环境存在、归宿和毒性）中一直被忽视。本文旨在介绍手性这一主题及其对环境污染的影响。特别关注了基于液相色谱-质谱联用的手性分析以及最常用的基于蛋白质的手性固定相的最新进展。讨论了几类与环境相关的cPACs，如非法药物、人用和兽用药品。手性环境分析领域发表的论文数量不断增加，这表明研究人员正在积极寻求新的机会，以便更好地理解cPACs对映体导致的环境影响。
