δ和γ生育三烯酚通过调节Ras-Raf-MEK-ERK通路相关上游信号来抑制人肝癌细胞增殖。
δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.
作者信息
Burdeos Gregor Carpentero, Ito Junya, Eitsuka Takahiro, Nakagawa Kiyotaka, Kimura Fumiko, Miyazawa Teruo
机构信息
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.
Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
出版信息
Food Funct. 2016 Oct 12;7(10):4170-4174. doi: 10.1039/c6fo00826g.
Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway.
生育三烯酚（T3）因其抗癌作用最近越来越受到关注。在此，我们研究了δ和γ生育三烯酚对人肝癌HepG2细胞中Ras-Raf-MEK-ERK致癌上游信号通路的调节作用。结果表明，生育三烯酚调节了该通路的上游信号级联反应。
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