Department of Advanced Pediatric Center (APC), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012, India.
Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012, India.
Int J Mol Sci. 2019 Feb 2;20(3):656. doi: 10.3390/ijms20030656.
Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various beneficial health promoting properties especially against chronic diseases, including cancer. The incidence of cancer is rapidly increasing around the world not only because of continual aging and growth in global population, but also due to the adaptation of Western lifestyle behaviours, including intake of high fat diets and low physical activity. Tocotrienols can suppress the growth of different malignancies, including those of breast, lung, ovary, prostate, liver, brain, colon, myeloma, and pancreas. These findings, together with the reported safety profile of tocotrienols in healthy human volunteers, encourage further studies on the potential application of these compounds in cancer prevention and treatment. In the current article, detailed information about the potential molecular mechanisms of actions of tocotrienols in different cancer models has been presented and the possible effects of these vitamin E analogues on various important cancer hallmarks, i.e., cellular proliferation, apoptosis, angiogenesis, metastasis, and inflammation have been briefly analyzed.
生育三烯酚，存在于多种天然来源中，如米糠、胭脂树种子和棕榈油，据报道具有多种有益的健康促进特性，特别是对慢性疾病，包括癌症。癌症的发病率在全球范围内迅速增加，不仅因为人口持续老龄化和增长，还因为西方生活方式行为的适应，包括摄入高脂肪饮食和低体力活动。生育三烯酚可以抑制不同恶性肿瘤的生长，包括乳腺癌、肺癌、卵巢癌、前列腺癌、肝癌、脑癌、结肠癌、骨髓瘤和胰腺癌。这些发现，加上在健康人类志愿者中报告的生育三烯酚的安全性概况，鼓励进一步研究这些化合物在癌症预防和治疗中的潜在应用。在本文中，详细介绍了生育三烯酚在不同癌症模型中的潜在分子作用机制，并简要分析了这些维生素 E 类似物对各种重要癌症特征的可能影响，即细胞增殖、细胞凋亡、血管生成、转移和炎症。
