Pan Fei, Shu Chao, Ye Long-Wu
State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Org Biomol Chem. 2016 Oct 12;14(40):9456-9465. doi: 10.1039/c6ob01774f.
N-Containing tricyclic compounds, especially the tricyclic N-heterocycles, are important structural motifs that possess significant potential in organic chemistry for their momentous applications in natural and man-made bioactive molecules. Gold catalysis, which exhibits specific catalytic properties in terms of both high reactivity and selectivity for various organic transformations, has proven to be a powerful tool for the straightforward synthesis of cyclic compounds, especially the polycyclic molecules. Currently, several approaches towards polycycle synthesis have been developed via gold-catalyzed transformations of readily available ynamides. In this review, we will focus on the recent advances in the gold-catalyzed construction of N-containing tricycles based on ynamides by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible.
含氮三环化合物，特别是三环氮杂环，是重要的结构基序，因其在天然和人造生物活性分子中的重大应用而在有机化学中具有巨大潜力。金催化在各种有机转化中表现出高反应性和选择性方面的特定催化特性，已被证明是直接合成环状化合物，特别是多环分子的有力工具。目前，已经通过金催化易得的烯酰胺转化开发了几种多环合成方法。在这篇综述中，我们将重点介绍基于烯酰胺的金催化含氮三环构建的最新进展，突出其特异性和适用性，并尽可能阐述其机理原理。
