糖尿病与骨髓脂肪化
Diabetes and Bone Marrow Adiposity.
作者信息
Kim Tiffany Y, Schafer Anne L
机构信息
University of California, San Francisco, 1700 Owens St, Room 349, San Francisco, CA, 94158, USA.
San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
出版信息
Curr Osteoporos Rep. 2016 Dec;14(6):337-344. doi: 10.1007/s11914-016-0336-x.
PURPOSE OF REVIEW
This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility.
RECENT FINDINGS
Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels of marrow fat in diabetes, human studies have shown smaller and less certain differences. Marrow fat has been reported to correlate with A1c, and there may be a distinct marrow lipid saturation profile in diabetes. Greater marrow fat is associated with impaired skeletal health. Marrow fat may be a mediator of skeletal fragility in diabetes. Circulating lipids, growth hormone alterations, visceral adiposity, and hypoleptinemia have been associated with greater marrow fat and may represent potential mechanisms for the putative effects of diabetes on marrow fat, although other factors likely contribute. Additional research is needed to further define the role of marrow fat in diabetic skeletal fragility and to determine whether marrow fat is a therapeutic target.
综述目的
本研究旨在描述糖尿病患者骨髓脂肪的变化，并探讨骨髓脂肪在骨骼脆性中的潜在作用。
最新发现
非侵入性成像技术的进步推动了人体骨髓脂肪研究。与动物研究明确显示糖尿病患者骨髓脂肪水平较高不同，人体研究显示的差异较小且不太确定。据报道，骨髓脂肪与糖化血红蛋白（A1c）相关，糖尿病患者可能存在独特的骨髓脂质饱和度特征。骨髓脂肪增加与骨骼健康受损有关。骨髓脂肪可能是糖尿病患者骨骼脆性的介导因素。循环脂质、生长激素改变、内脏肥胖和低瘦素血症与骨髓脂肪增加有关，可能代表糖尿病对骨髓脂肪假定作用的潜在机制，不过可能还有其他因素起作用。需要进一步研究以明确骨髓脂肪在糖尿病性骨骼脆性中的作用，并确定骨髓脂肪是否为治疗靶点。
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