Scheller Erica L, Cawthorn William P, Burr Aaron A, Horowitz Mark C, MacDougald Ormond A
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University, Saint Louis, MO 63110, USA.
University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Trends Endocrinol Metab. 2016 Jun;27(6):392-403. doi: 10.1016/j.tem.2016.03.016. Epub 2016 Apr 16.
Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions for MAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases. The diversity of these functions highlights the breadth of the potential impact of MAT on health and disease.
骨髓脂肪组织（MAT）是一种独特的脂肪储存库，位于骨骼中，有可能对局部和全身代谢过程产生影响。在本综述中，我们重点介绍了有关MAT脂肪细胞起源和功能的几个最新概念进展；探讨MAT与米色、棕色和白色脂肪储存库的关系；研究人类和啮齿动物中MAT的扩张和更新；并在内分泌功能和代谢疾病的背景下讨论MAT研究的未来方向。MAT有可能对代谢稳态、骨骼重塑、造血作用以及骨转移的发展产生局部和全身影响。这些功能的多样性突出了MAT对健康和疾病潜在影响的广度。
