艾迪生病的早期诊断；以色素沉着为唯一症状

Early diagnosis of Addison's disease; pigmentation as sole symptom.

作者信息

Strakosch C R, Gordon R D

出版信息

Aust N Z J Med. 1978 Apr;8(2):189-90. doi: 10.1111/j.1445-5994.1978.tb04510.x.

DOI:10.1111/j.1445-5994.1978.tb04510.x

Abstract

A diagnosis of primary adrenocortical insufficiency was made in a shapely, suntanned girl whose sole complaint was increasing pigmentation. Plasma cortisol was low in spite of markedly elevated levels of ACTH. Plasma cortisol, urinary 17-oxogenic steroids and urinary aldosterone did not respond to three days of ACTH stimulation. Addison's disease can be diagnosed and treated before development of anorexia, weight loss, weakness and other classical symptoms.

摘要

一名身材匀称、皮肤黝黑的女孩被诊断为原发性肾上腺皮质功能不全，她唯一的主诉是色素沉着加重。尽管促肾上腺皮质激素（ACTH）水平显著升高，但血浆皮质醇水平较低。血浆皮质醇、尿17-氧代类固醇和尿醛固酮对三天的ACTH刺激无反应。艾迪生病可在出现厌食、体重减轻、虚弱和其他典型症状之前得到诊断和治疗。