Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Paediatrics and Adolescent Medicine, Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark.
Fertil Steril. 2016 Dec;106(7):1757-1762.e1. doi: 10.1016/j.fertnstert.2016.09.001. Epub 2016 Oct 4.
To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse.
Retrospective case-control study.
University hospitals.
PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Follicular densities (follicles/mm) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored.
RESULT(S): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm vs. 327 ± 756/mm). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years).
CONCLUSION(S): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.
研究一线抗肿瘤治疗对因复发而接受卵巢组织冷冻保存（OTC）的年轻女孩卵巢储备的影响。
回顾性病例对照研究。
大学医院。
63 名年龄在 18 岁以下的女孩，她们在初次癌症治疗前（第 1 组：31 例）和治疗后（第 2 组：32 例）进行了 OTC。
无。
OTC 前卵巢皮质活检测量的卵泡密度（卵泡/mm）。同时监测用于 OTC 的整个卵巢切除的卵巢体积（mL）。
第 1 组和第 2 组的平均年龄或卵泡密度无统计学差异（334±476/mm 与 327±756/mm）。相比之下，在接受 OTC 前性腺毒性治疗的患者中，卵巢体积和冷冻保存的卵巢皮质芯片总数均有统计学显著降低（平均±标准差[SD]：卵巢体积分别为 5.3±3.1 和 2.9±2.1，皮质芯片数分别为 21.3±8.1 和 15.2±7.1）。儿童的估计卵巢储备减少 10%至 20%，青少年女孩（>10 岁）减少约 30%。
10 岁以下的女孩比青少年更能耐受性腺毒性损伤，一线性腺毒性治疗可能导致卵巢储备减少 30%，目前认为这对卵泡池几乎没有影响。这些信息将改善年轻女性癌症患者在决定是否进行生育力保存治疗时的咨询。
