Bouchnita Anass, Galochkina Tatiana, Volpert Vitaly
Camille Jordan Institute, University Lyon 1, Villeurbanne, 69622, France.
Laboratoire de Biométrie et Biologie Evolutive, UMR 5558 CNRS, University Lyon 1, 69376, Lyon, France.
Acta Biotheor. 2016 Dec;64(4):327-342. doi: 10.1007/s10441-016-9291-2. Epub 2016 Oct 7.
Blood coagulation is regulated through a complex network of biochemical reactions of blood factors. The main acting enzyme is thrombin whose propagation in blood plasma leads to fibrin clot formation. Spontaneous clot formation is normally controlled through the action of different plasma inhibitors, in particular, through the thrombin binding by antithrombin. In the current study we develop a mathematical model of clot formation both in quiescent plasma and in blood flow and determine the analytical conditions on the antithrombin concentration corresponding to different regimes of blood coagulation.
血液凝固是通过血液因子的复杂生化反应网络来调节的。主要起作用的酶是凝血酶，其在血浆中的传播会导致纤维蛋白凝块形成。自发性凝块形成通常通过不同血浆抑制剂的作用来控制，特别是通过抗凝血酶与凝血酶的结合。在当前研究中，我们建立了静态血浆和血流中凝块形成的数学模型，并确定了与不同血液凝固状态相对应的抗凝血酶浓度的分析条件。
