胃复安、氨甲酰甲胆碱和洛哌丁胺对胃内停留时间、胃排空及口至盲肠转运时间的影响。

Effect of metoclopramide, bethanechol, and loperamide on gastric residence time, gastric emptying, and mouth-to-cecum transit time.

作者信息

Kirby M G, Dukes G E, Heizer W D, Bryson J C, Powell J R

机构信息

University of North Carolina School of Pharmacy, Chapel Hill.

出版信息

Pharmacotherapy. 1989;9(4):226-31. doi: 10.1002/j.1875-9114.1989.tb04130.x.

DOI:10.1002/j.1875-9114.1989.tb04130.x

PMID:2771808

Abstract

The effects of metoclopramide, bethanechol, and loperamide on the gastric residence time (GRT), gastric emptying (GE), and mouth-to-cecum transit time (MCTT) of a solution were investigated in three separate studies of five healthy male volunteers each. Metoclopramide in doses of 5, 10, and 15 mg prolonged GRT by 33, 88, and 162%, respectively, almost reaching statistical significance (p 0.058). A relationship was observed between GRT prolongation, and metoclopramide area under the plasma-time curve (p 0.01) and metoclopramide observed time to maximum concentration (p 0.01). Metoclopramide had an inconsistent effect on MCTT. Bethanechol 50 mg prolonged GRT by 64% (p 0.031) and had no effect on MCTT. Loperamide at doses of 2 and 8 mg prolonged GRT by 18 and 115% (p 0.043) and MCTT by 30 and 130% (p 0.0001), respectively. None of these motility-altering agents affected GE.

摘要

在三项独立研究中，分别对五名健康男性志愿者进行了研究，以考察胃复安、氨甲酰甲胆碱和洛哌丁胺对溶液的胃内滞留时间（GRT）、胃排空（GE）和口至盲肠转运时间（MCTT）的影响。5毫克、10毫克和15毫克剂量的胃复安分别使GRT延长了33%、88%和162%，几乎达到统计学显著性（p = 0.058）。观察到GRT延长与胃复安血浆-时间曲线下面积（p = 0.01）以及胃复安达到最大浓度的观察时间（p = 0.01）之间存在相关性。胃复安对MCTT的影响不一致。50毫克氨甲酰甲胆碱使GRT延长了64%（p = 0.031），对MCTT无影响。2毫克和8毫克剂量的洛哌丁胺分别使GRT延长了18%和115%（p = 0.043），使MCTT延长了30%和130%（p = 0.0001）。这些改变动力的药物均未影响GE。