Van Wyk M, Sommers D K, Steyn A G
Br J Clin Pharmacol. 1985 Nov;20(5):479-81. doi: 10.1111/j.1365-2125.1985.tb05101.x.
The purpose of the study was to evaluate the validity of a model where intestinal transit is increased and decreased by motility modifying drugs. The measurement of breath hydrogen concentrations after ingestion of lactulose was used to estimate small intestinal transit time. After obtaining base-line values, eight healthy volunteers were pretreated on separate occasions with loperamide, diphenoxylate, metoclopramide and cisapride. Diphenoxylate caused a significant increase in small bowel transit time, whereas both metoclopramide and cisapride significantly shortened it. The H2 breath test therefore seems to accurately reflect the expected transit time. Loperamide did not alter significantly intestinal transit. Possibly this drug counteracts its own delaying influence on small bowel transit by hurrying gastric emptying. Alternatively, not enough time was allowed for it to exert its full effect.
本研究的目的是评估一种模型的有效性，在该模型中，通过调节动力的药物来增加和减少肠道转运。摄入乳果糖后测量呼气中氢气浓度，用于估计小肠转运时间。在获得基线值后，八名健康志愿者在不同时间分别接受洛哌丁胺、地芬诺酯、甲氧氯普胺和西沙必利预处理。地芬诺酯使小肠转运时间显著延长，而甲氧氯普胺和西沙必利均使其显著缩短。因此，氢气呼气试验似乎能准确反映预期的转运时间。洛哌丁胺对肠道转运没有显著影响。可能这种药物通过加快胃排空来抵消其自身对小肠转运的延迟作用。或者，没有给予足够的时间使其发挥全部作用。
