Favate Albert S, Younger David S
Division of Neuroepidemiology, Department of Neurology, New York University School of Medicine, New York, NY, USA.
Division of Neuroepidemiology, Department of Neurology, New York University School of Medicine, New York, NY, USA; College of Global Public Health, New York University, New York, NY, USA.
Neurol Clin. 2016 Nov;34(4):967-980. doi: 10.1016/j.ncl.2016.06.013.
Ischemic stroke is a heterogeneous multifactorial disorder recognized by the sudden onset of neurologic signs related directly to the sites of injury in the brain where the morbid process occurs. The evaluation of complex neurologic disorders, such as stroke, in which multiple genetic and epigenetic factors interact with environmental risk factors to increase the risk has been revolutionized by the genome-wide association studies (GWAS) approach. This article reviews salient aspects of ischemic stroke emphasizing the impact of neuroepidemiology and GWAS.
缺血性中风是一种异质性多因素疾病，其特征是与脑部损伤部位直接相关的神经体征突然出现，而脑部损伤部位正是发病过程发生的地方。对于中风等复杂神经系统疾病的评估已经因全基因组关联研究（GWAS）方法而发生了变革，在这些疾病中，多种遗传和表观遗传因素与环境风险因素相互作用，增加了发病风险。本文回顾了缺血性中风的显著方面，重点强调了神经流行病学和全基因组关联研究的影响。
