Liu Yunpeng, Dong Jing, Zhang Ziqing, Liu Yiqi, Wang Yang
Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Department of Medical Engineering, Tsinghua University Yuquan Hospital, Beijing, China.
Front Neurosci. 2022 May 24;16:877937. doi: 10.3389/fnins.2022.877937. eCollection 2022.
Ischemic stroke (IS) is among the top prevalent neurologic disorders globally today. Risk factors such as hypertension, diabetes, and aging, contribute to the development of IS, and patients with these risk factors face heavier therapeutic burden and worse prognosis. Microbiota-gut-brain axis describes the crosstalk between the gut flora, intestine, and center nervous system, which conduct homeostatic effects through the bacterial metabolites, the regulation of immune activity, also the contact with enteric nerve ends and vagus nerve. Nowadays, more studies have paid attention to the important roles that microbiota-gut-brain axis played in the risk factors of IS. In the current article, we will review the recent works focusing on the bi-directional impacts of gut dysbiosis and the pathogenic process of IS-related risk factors, for the purpose to summarize some novel findings in this area, and try to understand how probiotics could limit the development of IS different strategies.
缺血性中风（IS）是当今全球最常见的神经系统疾病之一。高血压、糖尿病和衰老等风险因素会导致IS的发生，患有这些风险因素的患者面临着更重的治疗负担和更差的预后。微生物群-肠道-脑轴描述了肠道菌群、肠道和中枢神经系统之间的相互作用，它们通过细菌代谢产物、免疫活动的调节以及与肠神经末梢和迷走神经的接触来发挥稳态作用。如今，越来越多的研究关注微生物群-肠道-脑轴在IS风险因素中所起的重要作用。在本文中，我们将综述最近关于肠道菌群失调与IS相关风险因素致病过程的双向影响的研究工作，目的是总结该领域的一些新发现，并尝试了解益生菌如何通过不同策略限制IS的发展。
