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低收入环境下的心脏手术:来自两个国家的10年经验。

Cardiac surgery in low-income settings: 10 years of experience from two countries.

作者信息

Mirabel Mariana, Lachaud Matthias, Offredo Lucile, Lachaud Cécile, Zuschmidt Benjamin, Ferreira Beatriz, Sidi Daniel, Chauvaud Sylvain, Sok Phang, Deloche Alain, Marijon Eloi, Jouven Xavier

机构信息

Inserm U970, Paris Cardiovascular Research Centre, European Georges-Pompidou Hospital, 56, rue Leblanc, 75737 Paris, France; Paris Descartes University, 75005 Paris, France; Cardiology Department, European Georges-Pompidou Hospital, 75015 Paris, France.

Instituto do Coração (ICOR), 1100 Maputo, Mozambique; Institut du Thorax, 44093 Nantes cedex 1, France.

出版信息

Arch Cardiovasc Dis. 2017 Feb;110(2):82-90. doi: 10.1016/j.acvd.2016.05.006. Epub 2016 Oct 4.

Abstract

BACKGROUND

Access to cardiac surgery is limited in low-income settings, and data on patient outcomes are scarce.

AIMS

To assess characteristics, surgical procedures and outcomes in patients undergoing open-heart surgery in low-income settings.

METHODS

This was a cohort study (2001-2011) in two low-income countries, Cambodia and Mozambique, where cardiac surgery had been promoted by visiting non-governmental organizations.

RESULTS

In Cambodia and Mozambique, respectively, 1332 and 767 consecutive patients were included; 547 (41.16%) and 385 (50.20%) were men; median age at first surgery was 11 years (interquartile range [IQR] 4-14) and 11 years (IQR 3-18); rheumatic heart disease affected 490 (36.79%) and 268 (34.94%) patients; congenital heart disease (CHD) affected 834 (62.61%) and 390 (50.85%) patients, with increasingly more CHD patients over time (P<0.001); and the number of patients lost to follow-up reached 741 (55.63%) and 112 (14.6%) at 30 days. A total of 249 (32.46%) patients were lost to follow-up in Mozambique, remoteness being the only influencing factor (P<0.001). Among patients with known vital status, the early (<30 days) postoperative mortality rate was 6.10% (n=40) in Mozambique and 3.05% (n=18) in Cambodia. Overall, 109 (8.18%) patients in Cambodia and 94 (12.26%) patients in Mozambique underwent re-do surgery. In Mozambique, a further 50/518 (9.65%) patients died at a median of 23months (IQR 7-43); in Cambodia, a further 34/591 (5.75%) patients died at a median of 11.5months (IQR 6-54.5).

CONCLUSIONS

Cardiac surgery is feasible in low-income countries with acceptable in-hospital mortality and proof of capacity building. Patient outcomes after cardiac surgery in low-income countries remain unknown, given the strikingly high numbers of lost to follow-up.

摘要

背景

在低收入地区,心脏手术的可及性有限,且关于患者预后的数据稀缺。

目的

评估低收入地区接受心脏直视手术患者的特征、手术方式及预后。

方法

这是一项队列研究(2001 - 2011年),在柬埔寨和莫桑比克这两个低收入国家开展,心脏手术由来访的非政府组织推动开展。

结果

在柬埔寨和莫桑比克,分别纳入了1332例和767例连续患者;男性分别为547例(41.16%)和385例(50.20%);首次手术时的中位年龄在柬埔寨为11岁(四分位间距[IQR]4 - 14),在莫桑比克为11岁(IQR 3 - 18);风湿性心脏病患者分别为490例(36.79%)和268例(34.94%);先天性心脏病(CHD)患者分别为834例(62.61%)和390例(50.85%),且随着时间推移CHD患者数量不断增加(P<0.001);30天时失访患者数量在柬埔寨达741例(55.63%),在莫桑比克达112例(14.6%)。在莫桑比克,共有249例(32.46%)患者失访,偏远地区是唯一的影响因素(P<0.001)。在已知存活状态的患者中,莫桑比克术后早期(<30天)死亡率为6.10%(n = 40),柬埔寨为3.05%(n = 18)。总体而言,柬埔寨有109例(8.18%)患者、莫桑比克有94例(12.26%)患者接受了再次手术。在莫桑比克,另有50/518例(9.65%)患者在中位时间23个月(IQR 7 - 43)时死亡;在柬埔寨,另有34/591例(5.75%)患者在中位时间11.5个月(IQR 6 - 54.5)时死亡。

结论

在低收入国家,心脏手术是可行的,住院死亡率可接受且有能力建设的证据。鉴于失访人数惊人之多,低收入国家心脏手术后患者的预后情况仍不明朗。

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