de la Torre-Escudero Eduardo, Bennett Adam P S, Clarke Alexzandra, Brennan Gerard P, Robinson Mark W
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK.
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK.
Trends Parasitol. 2016 Dec;32(12):921-929. doi: 10.1016/j.pt.2016.09.001. Epub 2016 Oct 5.
The recent discovery that parasites release extracellular vesicles (EVs) that can transfer a range of effector molecules to host cells has made us re-think our understanding of the host-parasite interface. In this opinion article we consider how recent proteomics and transcriptomics studies, together with ultrastructural observations, suggest that more than one mechanism of EV biogenesis can occur in helminths. We propose that distinct EV subtypes have roles in immune modulation and repair of drug-induced damage, and put forward the case for targeting EV biogenesis pathways to achieve parasite control. In doing so we raise a number of outstanding research questions that must be addressed before this can happen.
最近发现寄生虫会释放细胞外囊泡（EVs），这些囊泡能够将一系列效应分子转移至宿主细胞，这使我们重新思考对宿主-寄生虫界面的理解。在这篇观点文章中，我们探讨了近期的蛋白质组学和转录组学研究，以及超微结构观察结果，这些研究表明蠕虫中可能存在不止一种细胞外囊泡生物发生机制。我们提出，不同的细胞外囊泡亚型在免疫调节和药物诱导损伤的修复中发挥作用，并主张靶向细胞外囊泡生物发生途径来实现对寄生虫的控制。在此过程中，我们提出了一些在实现这一目标之前必须解决的重要研究问题。
