Mateen Somaiya, Moin Shagufta, Zafar Atif, Khan Abdul Qayyum
Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India.
Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India.
Clin Chim Acta. 2016 Dec 1;463:4-10. doi: 10.1016/j.cca.2016.10.007. Epub 2016 Oct 6.
Rheumatoid arthritis (RA) is an autoimmune, inflammatory joint disease whose exact cause is still not completely known. Reactive oxygen species (ROS) are believed to be involved in the pathogenesis of RA. ROS are produced mostly by the phagocytic cells during oxidative burst and oxidative phosphorylation. Lipids, proteins and nucleic acids get damaged by the overproduction of ROS. Damaging effects of ROS are taken care by the enzymatic and non-enzymatic defence system of the body. Overproduction or inadequate elimination of reactive species leading to oxidative stress has been positively correlated with the disease severity in RA patients. ROS activates signal transduction pathways involved in the inflammatory response in RA. Understanding the complex interplay between signaling pathways might be useful for the development of new and effective therapeutics for RA. In this review we discuss the involvement of reactive species in the pathogenesis of RA and their elimination by antioxidant defence system. Role of various antioxidants/polyphenols which looks quite promising in the treatment of RA have also been discussed.
类风湿性关节炎（RA）是一种自身免疫性炎症性关节疾病，其确切病因仍不完全清楚。活性氧（ROS）被认为参与了RA的发病机制。ROS主要由吞噬细胞在氧化爆发和氧化磷酸化过程中产生。脂质、蛋白质和核酸会因ROS的过度产生而受损。ROS的损伤作用由机体的酶促和非酶促防御系统来处理。活性物质的过度产生或清除不足导致氧化应激，这与RA患者的疾病严重程度呈正相关。ROS激活了RA炎症反应中涉及的信号转导通路。了解信号通路之间的复杂相互作用可能有助于开发针对RA的新型有效疗法。在这篇综述中，我们讨论了活性物质在RA发病机制中的作用以及抗氧化防御系统对它们的清除。还讨论了各种抗氧化剂/多酚在RA治疗中颇具前景的作用。
