Tiwari Priyanka, Singh Nitika, Sharma Bechan
Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad, 211002 India.
Indian J Clin Biochem. 2023 Apr 1;39(2):1-9. doi: 10.1007/s12291-023-01127-2.
Arthritis is a clinical condition, which mainly affects the structure and function joints. During this condition the joints gets swelled and stiffed resulting into development of pain and morbidity. Corticosteroids are frequently prescribed to manage various clinical conditions including the chronic inflammatory diseases such as arthritis. The steroidal drug also causes certain adverse effects depending on the dose, the route of administration and duration of treatment. However, a systematic investigation on the biochemical consequences of steroids as a therapeutic has not been carried out. In the present study we analyzed certain parameters associated to oxidative stress, liver function and energy metabolism has been done in the blood plasma of the arthritis patients who were using steroidal drugs (methylprednisolone and deflazacort) up to 168 days for the treatment of the disease. The results indicated increase in level of MDA and decrease in the activities of SOD, CAT and LDH. The activities of AST and ALT were found to be significantly enhanced over the increase in the treatment period. These results suggested that corticosteroids may induce lipid peroxidation, oxidative stress and liver toxicity in the arthritis patients in the dose and duration dependent manner. The use of antioxidants as supplements to the anti-arthritis agents could play a role in suppressing the oxidative stress mediated adverse effects. However, extensive research is required to explore for safer medication devoid of steroids to cure arthritis.
关节炎是一种临床病症，主要影响关节的结构和功能。在此病症期间，关节会肿胀和僵硬，进而导致疼痛和发病。皮质类固醇经常被用于治疗各种临床病症，包括如关节炎等慢性炎症性疾病。这种甾体药物也会根据剂量、给药途径和治疗持续时间产生某些不良反应。然而，尚未对类固醇作为治疗药物的生化后果进行系统研究。在本研究中，我们分析了使用甾体药物（甲泼尼龙和地夫可特）长达168天治疗疾病的关节炎患者血浆中与氧化应激、肝功能和能量代谢相关的某些参数。结果表明丙二醛水平升高，超氧化物歧化酶、过氧化氢酶和乳酸脱氢酶活性降低。在治疗期间，天冬氨酸转氨酶和丙氨酸转氨酶的活性随着时间的增加而显著增强。这些结果表明，皮质类固醇可能以剂量和持续时间依赖的方式在关节炎患者中诱导脂质过氧化、氧化应激和肝毒性。使用抗氧化剂作为抗关节炎药物的补充剂可能在抑制氧化应激介导的不良反应中发挥作用。然而，需要进行广泛的研究以探索更安全的无类固醇药物来治疗关节炎。
