Newman M M, Halmi K A
Eating Disorders Program, Fair Oaks Hospital, Summit, NJ 07901.
Psychiatry Res. 1989 Jul;29(1):105-12. doi: 10.1016/0165-1781(89)90190-x.
Dual photon absorptiometry was used to assess the risk of developing osteoporosis in patients with anorexia nervosa and patients of normal weight with bulimia nervosa. Anorectic patients had significantly lower vertebral bone mineral densities compared with healthy controls. Bulimic patients had values similar to those of controls, and the differences between bulimics and anorectics narrowly missed significance. No significant difference was found between patient groups in measurements of serum estradiol, but anorectics, compared with bulimics, had significantly higher values of 24-hour urinary free cortisol. Hypercortisolemia, by diminishing bone formation and increasing bone resorption, is likely to contribute to the development of osteoporosis in patients with eating disorders.
采用双能X线吸收法评估神经性厌食症患者和神经性贪食症正常体重患者发生骨质疏松症的风险。与健康对照组相比，神经性厌食症患者的椎体骨密度显著降低。神经性贪食症患者的骨密度值与对照组相似，且神经性贪食症患者与神经性厌食症患者之间的差异略低于显著性水平。两组患者血清雌二醇测量值无显著差异，但与神经性贪食症患者相比，神经性厌食症患者24小时尿游离皮质醇值显著更高。高皮质醇血症通过减少骨形成和增加骨吸收，可能导致饮食失调患者骨质疏松症的发生。
