Davies R W, Hall W S
Br J Cancer Suppl. 1978 Jun;3:154-8.
Direct measurements using 200 micron oxygen cathode electordes have been made in tumour and subcutaneous tissues of anaesthetized C3H mice treated with misonidazole. In air-breathing animals a six-fold increase in tumour oxygen cathode readings was observed by 23 min after i.p. injection of misonidazole at 0.5 mg/g body weight. A similar rise, but of 2.5 times, was observed for the subcutaneous tissues. Comparison of tumour oxygen readings for drug-treated and control mice breathing 100% O2 at different pressures showed markedly increased levels for the drug-treated animals. Tumour response to radiation was measured for 250 kV X-rays and 15 MeV electrons. In each case, when a dose of radiation was combined with pre-treatement with misonidazole an increased radiation response was observed when compared with the same dose of radiation given alone. At the highest dose (40 Gy) there was a suggestion of an increased normal tissue reaction. The significance of the measurements is discussed.
使用200微米氧阴极电极对接受米索硝唑治疗的麻醉C3H小鼠的肿瘤组织和皮下组织进行了直接测量。在呼吸空气的动物中，腹腔注射0.5mg/g体重的米索硝唑后23分钟，观察到肿瘤氧阴极读数增加了6倍。皮下组织也观察到类似的升高，但为2.5倍。比较在不同压力下呼吸100%氧气的药物治疗小鼠和对照小鼠的肿瘤氧读数，结果显示药物治疗动物的水平明显升高。测量了250 kV X射线和15 MeV电子对肿瘤的反应。在每种情况下，当将一定剂量的辐射与米索硝唑预处理相结合时，与单独给予相同剂量的辐射相比，观察到辐射反应增加。在最高剂量（40 Gy）时，有迹象表明正常组织反应增加。讨论了这些测量结果的意义。
