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1
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Br J Cancer Suppl. 1978 Jun;3:178-83.
2
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Tumour-specific enhancement of thermoradiotherapy at mild temperatures by the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid.血管靶向剂5,6-二甲基呫吨酮-4-乙酸在温和温度下对热放疗的肿瘤特异性增强作用。
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Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue.米索硝唑与热疗对C3H小鼠乳腺癌及其周围正常组织放射敏感性的影响。
Br J Cancer. 1980 Jan;41(1):10-21. doi: 10.1038/bjc.1980.2.
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Combined effects of misonidazole, microwave hyperthermia, and X-rays on the in vivo sister chromatid exchanges and chromosomal abnormalities of the dbrB tumor and on the survival of its host.灭滴灵、微波热疗和X射线对dbrB肿瘤体内姐妹染色单体交换和染色体异常及其宿主存活的联合作用。
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Radiother Oncol. 2008 Jun;87(3):331-8. doi: 10.1016/j.radonc.2008.03.002. Epub 2008 Mar 28.
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Studies in radiosensitizing effects of misonidazole and SR-2508 on C3H/He mouse mammary tumors.米索硝唑和SR-2508对C3H/He小鼠乳腺肿瘤的放射增敏作用研究。
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引用本文的文献

1
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Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia.热疗：克服放射抗性缺氧的最佳治疗方法。
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Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue.米索硝唑与热疗对C3H小鼠乳腺癌及其周围正常组织放射敏感性的影响。
Br J Cancer. 1980 Jan;41(1):10-21. doi: 10.1038/bjc.1980.2.
4
Enhancement of hyperthermochemotherapy for human gastric cancer in nude mice by thermosensitization with nitroimidazoles.用硝基咪唑类药物进行热致敏增强裸鼠人胃癌热化学疗法
Br J Cancer. 1988 Jul;58(1):42-5. doi: 10.1038/bjc.1988.158.
5
Effect of local hyperthermia on the acute toxicity of misonidazole in mice.局部热疗对小鼠米索硝唑急性毒性的影响。
Br J Cancer. 1979 Jan;39(1):96-8. doi: 10.1038/bjc.1979.12.

本文引用的文献

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The effects of heat and radiation on cancers implanted on the feet of mice.热和辐射对移植于小鼠足部的癌症的影响。
Cancer Res. 1963 Mar;23:372-80.
2
Investigations on the possibility of a thermic tumour therapy. I. Short-wave treatment of a transplanted isologous mouse mammary carcinoma.关于温热肿瘤治疗可能性的研究。I. 对移植的同基因小鼠乳腺癌进行短波治疗。
Eur J Cancer (1965). 1972 Feb;8(1):65-78. doi: 10.1016/0014-2964(72)90085-0.
3
Radiotherapy of a mouse mammary carcinoma following treatment with 5-iodo-2'-deoxyuridine.用5-碘-2'-脱氧尿苷治疗后小鼠乳腺癌的放射治疗。
Radiology. 1974 Sep;112(3):719-25. doi: 10.1148/112.3.719.
4
Increased cures using fractionated exposures of X irradiation and hyperthermia in the local treatment of the Ridgway osteogenic sarcoma in mice.在小鼠Ridgway骨肉瘤的局部治疗中，使用分次X线照射和热疗可提高治愈率。
Radiology. 1974 Oct;113(1):199-202. doi: 10.1148/113.1.199.
5
Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.一种2-硝基咪唑类药物对C3H小鼠乳腺肿瘤的放射增敏作用。
Br J Cancer. 1974 Dec;30(6):560-5. doi: 10.1038/bjc.1974.235.
6
Selective heat sensitivity of cancer cells. Biochemical and clinical studies.癌细胞的选择性热敏感性。生化与临床研究。
Cancer. 1967 Sep;20(9):1351-81. doi: 10.1002/1097-0142(196709)20:9<1351::aid-cncr2820200902>3.0.co;2-#.
7
Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.用硝基咪唑类药物甲硝唑和Ro 7-0582对小鼠肿瘤缺氧细胞进行选择性放射增敏。
Radiat Res. 1975 Dec;64(3):633-47.
8
Hypoxic sensitizers: radiobiological studies at the cellular level.缺氧敏化剂：细胞水平的放射生物学研究
Radiology. 1975 Nov;117(2):453-7. doi: 10.1148/117.2.453.
9
Effect of heat and ionizing radiation on normal and neoplastic tissue of the C3H mouse.热和电离辐射对C3H小鼠正常组织和肿瘤组织的影响。
Radiat Res. 1975 Aug;63(2):363-77.
10
Letter: Enhancement of the radioresponse of a murine tumour by a nitroimidazone.信件：一种硝唑咪增强小鼠肿瘤的放射反应
Br J Radiol. 1975 May;48(569):411-2. doi: 10.1259/0007-1285-48-569-411.

甲硝唑与热疗联合增强局部肿瘤控制效果

Enhancement of local tumour control by misonidazole and hyperthermia.

作者信息

Stone H B

出版信息

Br J Cancer Suppl. 1978 Jun;3:178-83.

PMID:277222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149415/
Abstract

Combination treatment of a C3H mammary carcinoma with misonidazole, hyperthermia and radiation resulted in greater local tumour control than with any of these agents singly or in pairs. Dose modification factors for the 3-fold combinations were 3.28 when tumours were immersed in a 42.5 degree C waterbath for 1h after irradiation, and 5.03 at 43.0 degrees C. Cytotoxicity of misonidazole alone was slight, as reflected histologically and in tumour growth. Hyperthermia had a marked effect on these two parameters. Foot damage by hyperthermia was greatest when feet were taped.

摘要

用甲硝唑、热疗和放疗联合治疗C3H乳腺癌，其局部肿瘤控制效果优于单独使用这些药物或两两联合使用。当肿瘤在照射后浸入42.5℃水浴1小时，三联疗法的剂量修正因子为3.28；在43.0℃时为5.03。单独使用甲硝唑的细胞毒性轻微，这在组织学和肿瘤生长方面都有体现。热疗对这两个参数有显著影响。当脚部被包扎时，热疗造成的脚部损伤最大。