Ricciuti Biagio, Leonardi Giulia Costanza, Ravaioli Noemi, De Giglio Andrea, Brambilla Marta, Prosperi Enrico, Ribacchi Franca, Meacci Marialuisa, Crinò Lucio, Maiettini Daniele, Chiari Rita, Metro Giulio
Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
Department of Experimental Medicine and Biochemical Sciences, Section of Anatomic Pathology and Histology, University of Perugia, Perugia, Italy.
J Breast Cancer. 2016 Sep;19(3):324-329. doi: 10.4048/jbc.2016.19.3.324. Epub 2016 Sep 23.
Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.
乳腺癌转移至胃肠道极为罕见。在乳腺癌的组织学亚型中，浸润性小叶癌转移至包括胃在内的不常见部位的能力较强。相反，尚无充分证据支持浸润性导管癌发生胃转移。在此，我们报告一例男性患者中转移性导管乳腺癌酷似原发性皮革胃的独特病例，特别关注其临床表现和病理特征。此外，我们提出一组免疫组化抗体组合，包括细胞角蛋白20、细胞角蛋白7、雌激素受体、孕激素受体、E-钙黏蛋白、巨大囊肿病液体蛋白15和GATA结合蛋白3，以进行准确的鉴别诊断。
