Ito Akane, Nakatsubo Masaki, Yoshino Ryusei, Yoshida Nana, Kitada Masahiro
Surgery, Asahikawa Medical University, Asahikawa, JPN.
Thoracic Surgery and Breast Surgery, Asahikawa Medical University Hospital, Asahikawa-shi, JPN.
Cureus. 2023 Aug 13;15(8):e43434. doi: 10.7759/cureus.43434. eCollection 2023 Aug.
Gastric metastases from breast cancer are difficult to distinguish from primary gastric cancer. We report two cases of gastric metastasis of breast cancer with a review of the literature. In the first case, a 77-year-old woman was diagnosed with adenocarcinoma after upper gastrointestinal endoscopy, which revealed an erosive lesion in the gastric corpus. She was treated with an aromatase inhibitor and a CDK4/6 inhibitor, but five years later, she developed multiple bone metastases and gastric lesions, and she is currently receiving weekly paclitaxel (PTX) and bev. In the second case, a 63-year-old woman underwent total mastectomy and axillary lymphadenectomy [invasive lobular carcinoma (ILC)]. Eleven years after the surgery, the patient complained of pharyngeal tightness, and upper gastrointestinal endoscopy revealed a type 4 gastric tumor in the gastric body and posterior wall. In conclusion, when a patient with ILC or advanced breast cancer presents with gastric symptoms and anemia, it is important to examine and treat the patient based on the possibility of gastric metastasis.
乳腺癌的胃转移瘤很难与原发性胃癌区分开来。我们报告两例乳腺癌胃转移病例并对文献进行综述。第一例中，一名77岁女性在上消化道内镜检查后被诊断为腺癌，内镜显示胃体有糜烂性病变。她接受了芳香化酶抑制剂和CDK4/6抑制剂治疗，但五年后，她出现了多处骨转移和胃部病变，目前正在接受每周一次的紫杉醇（PTX）和贝伐单抗治疗。第二例中，一名63岁女性接受了全乳切除术和腋窝淋巴结清扫术[浸润性小叶癌（ILC）]。手术后11年，患者主诉咽部发紧，上消化道内镜检查发现胃体和后壁有4型胃肿瘤。总之，当ILC患者或晚期乳腺癌患者出现胃部症状和贫血时，基于胃转移的可能性对患者进行检查和治疗很重要。
